Evidence map›Paper›PMID 23893450›Full record

ReviewMovement disorders : official journal of the Movement Disorder Society2013

The focal dystonias: current views and challenges for future research.

H A Jinnah, Alfredo Berardelli, Cynthia Comella, Giovanni Defazio, Mahlon R Delong, Stewart Factor, Wendy R Galpern, Mark Hallett, Christy L Ludlow, Joel S Perlmutter and 2 more

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Movement disorders : official journal of the Movement Disorder Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 110 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 4 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02577224 nacompletednot on this mapstarted 2015, after this paper: background citation

A Randomised Controlled Trial to Explore the Effectiveness and Cost-effectiveness of a Patient-initiated Botulinum Toxin Treatment Model for Blepharospasm and Hemifacial Spasm Compared to Treatment as Usual

TypeinterventionalSponsorMoorfields Eye Hospital NHS Foundation TrustRan2015 to 2018Enrolled130ConditionsBlepharospasm, Hemi Facial SpasmArmsPatient-initiated treatment
NCT03471923 completednot on this mapstarted 2018, after this paper: background citation

Non-Motor Features of Cervical Dystonia

TypeobservationalSponsorVanderbilt University Medical CenterRan2018 to 2019Enrolled33ConditionsCervical Dystonia, Movement Disorders, Focal Dystonia, Signs and SymptomsArmsNeurological Examination, Assessment of Non-Motor Features
3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 4 syntheses or guidelines pooled it, 210 citations in OpenAlex.

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  16. Oromandibular dystonia: from onset to spread a multicenter italian study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  17. Sex Differences in Dystonia.Movement disorders clinical practice · 2024
    Article
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50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 2 countries.

H A JinnahDepartment of Neurology, Emory University, Atlanta, Georgia 30322, USA. hjinnah@emory.edu
Alfredo Berardelli
Cynthia Comella
Giovanni Defazio
Mahlon R Delong
Stewart Factor
Wendy R Galpern
Mark Hallett
Christy L Ludlow
Joel S Perlmutter
Ami R Rosen
Dystonia Coalition Investigators
Emory University · USJames Madison University · USNational Institute of Neurological Disorders and Stroke · USNational Institutes of Health · USRush University Medical Center · USSapienza University of Rome · ITUniversity of Bari Aldo Moro · ITWashington University in St. Louis · US

Funding

Pathophysiology of Basal Ganglia DisordersZIANS003031 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI HALLETT, MARK · 2009 to 2023
$22.7M
INVESTIGATIONS OF DEMENTIA IN PARKINSON DISEASER01NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2011 to 2021
$8.2M
Dystonia CoalitionU54NS065701 · NINDS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2009 to 2014
$7.0M
MECHANISMS OF DEEP BRAIN STIMULATIONR01NS041509 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2001 to 2015
$6.8M
Dystonia CoalitionU54TR001456 · NCATS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2015 to 2016
$2.5M
NEUROBIOLOGY OF DYSTONIAR01NS040470 · NINDS · JOHNS HOPKINS UNIVERSITY · PI JINNAH, HYDER A · 2000 to 2008
$2.5M
Investigations of Dementia in Parkinson DiseaseRF1NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2023 to 2023
$2.3M
NCATS NIH HHS U54 TR001456NINDS NIH HHS R01 NS040470NINDS NIH HHS R01 NS041509NINDS NIH HHS R01 NS075321NINDS NIH HHS RF1 NS075321NINDS NIH HHS U54 NS065701
6 · The paper itself

Abstract

The most common forms of dystonia are those that develop in adults and affect a relatively isolated region of the body. Although these adult-onset focal dystonias are most prevalent, knowledge of their etiologies and pathogenesis has lagged behind some of the rarer generalized dystonias, in which the identification of genetic defects has facilitated both basic and clinical research. This summary provides a brief review of the clinical manifestations of the adult-onset focal dystonias, focusing attention on less well understood clinical manifestations that need further study. It also provides a simple conceptual model for the similarities and differences among the different adult-onset focal dystonias as a rationale for lumping them together as a class of disorders while at the same time splitting them into subtypes. The concluding section outlines some of the most important research questions for the future. Answers to these questions are critical for advancing our understanding of this group of disorders and for developing novel therapeutics.

Indexed as

Biomedical ResearchDystonic DisordersHumansblepharospasmcervical dystoniafocal dystoniafocal hand dystoniaspasmodic dysphonia

Identifiers

PMID23893450
PMCPMC3733486
OpenAlexW2148265992

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.