ArticleClinical orthopaedics and related research2013
No effect of hole geometry in microfracture for talar osteochondral defects.
Article in Clinical orthopaedics and related research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- The Subchondral Bone Is Affected by Bone Marrow Stimulation: A Systematic Review of Preclinical Animal Studies.Cartilage · 2019Pooled it
- Subchondral drilling for articular cartilage repair: a systematic review of translational research.Disease models & mechanisms · 2018Pooled it
- Clinical and Magnetic Resonance Imaging Outcomes After Human Cord Blood-Derived Mesenchymal Stem Cell Implantation for Chondral Defects of the Knee.Orthopaedic journal of sports medicine · 2023Article
- Outcomes of Bone Marrow Stimulation for Secondary Osteochondral Lesions of the Talus Equal Outcomes for Primary Lesions.Cartilage · 2021Article
- Article
- Osteochondral lesions of the talus in the athlete: up to date review.Current reviews in musculoskeletal medicine · 2017Review
- The biology and clinical evidence of microfracture in hip preservation surgery.Journal of hip preservation surgery · 2016Review
- [Arthroscopic treatment of chondral lesions of the ankle joint. Evidence-based therapy].Der Unfallchirurg · 2016Review
- What quantitative mechanical loading stimulates in vitro cultivation best?Journal of experimental orthopaedics · 2015Article
- The use of nano-computed tomography to enhance musculoskeletal research.Connective tissue research · 2015Article
- Microcomputed tomography: approaches and applications in bioengineering.Stem cell research & therapy · 2014Review
- Strategies for osteochondral repair: Focus on scaffolds.Journal of tissue engineering · 2014Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDébridement and bone marrow stimulation is an effective treatment option for patients with talar osteochondral defects. However, whether surgical factors affect the success of microfracture treatment of talar osteochondral defects is not well characterized. QUESTIONS/PURPOSES: We hypothesized (1) holes that reach deeper into the bone marrow-filled trabecular bone allow for more hyaline-like repair; and (2) a larger number of holes with a smaller diameter result in more solid integration of the repair tissue, less need for new bone formation, and higher fill of the defect.
methodsTalar osteochondral defects that were 6 mm in diameter were drilled bilaterally in 16 goats (32 samples). In eight goats, one defect was treated by drilling six 0.45-mm diameter holes in the defect 2 mm deep; in the remaining eight goats, six 0.45-mm diameter holes were punctured to a depth of 4 mm. All contralateral defects were treated with three 1.1-mm diameter holes 3 mm deep, mimicking the clinical situation, as internal controls. After 24 weeks, histologic analyses were performed using Masson-Goldner/Safranin-O sections scored using a modified O'Driscoll histologic score (scale, 0-22) and analyzed for osteoid deposition. Before histology, repair tissue quality and defect fill were assessed by calculating the mean attenuation repair/healthy cartilage ratio on Equilibrium Partitioning of an Ionic Contrast agent (EPIC) micro-CT (μCT) scans. Differences were analyzed by paired comparison and Mann-Whitney U tests.
resultsSignificant differences were not present between the 2-mm and 4-mm deep hole groups for the median O'Driscoll score (p = 0.31) and the median of the μCT attenuation repair/healthy cartilage ratios (p = 0.61), nor between the 0.45-mm diameter and the 1.1-mm diameter holes in defect fill (p = 0.33), osteoid (p = 0.89), or structural integrity (p = 0.80).
conclusionsThe results indicate that the geometry of microfracture holes does not influence cartilage healing in the caprine talus. CLINICAL RELEVANCE: Bone marrow stimulation technique does not appear to be improved by changing the depth or diameter of the holes.
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