ArticleScientific reports2013
Prefrontal cortical microcircuits bind perception to executive control.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- The modular organization of the cerebral cortex: Evolutionary significance and possible links to neurodevelopmental conditions.The Journal of comparative neurology · 2019Review
- Human Brain/Cloud Interface.Frontiers in neuroscience · 2019Article
- Thalamic Control of Cognition and Social Behavior Via Regulation of Gamma-Aminobutyric Acidergic Signaling and Excitation/Inhibition Balance in the Medial Prefrontal Cortex.Biological psychiatry · 2018Article
- What Is the Evidence for Inter-laminar Integration in a Prefrontal Cortical Minicolumn?Frontiers in neuroanatomy · 2017Article
- Spike-Based Bayesian-Hebbian Learning of Temporal Sequences.PLoS computational biology · 2016Article
- Neostriatal Neuronal Activity Correlates Better with Movement Kinematics under Certain Rewards.Frontiers in neuroscience · 2016Article
- Disruption of columnar and laminar cognitive processing in primate prefrontal cortex following cocaine exposure.Frontiers in systems neuroscience · 2015Article
- Advancing brain-machine interfaces: moving beyond linear state space models.Frontiers in systems neuroscience · 2015Article
- A novel wireless recording and stimulating multichannel epicortical grid for supplementing or enhancing the sensory-motor functions in monkey (Macaca fascicularis).Frontiers in systems neuroscience · 2015Article
- Fetal alcohol spectrum disorders.European child & adolescent psychiatry · 2014Review
- Prefrontal cortical minicolumn: from executive control to disrupted cognitive processing.Brain : a journal of neurology · 2014Review
- Volitional enhancement of firing synchrony and oscillation by neuronal operant conditioning: interaction with neurorehabilitation and brain-machine interface.Frontiers in systems neuroscience · 2014Review
- Brain-machine interfaces can accelerate clarification of the principal mysteries and real plasticity of the brain.Frontiers in systems neuroscience · 2014Article
- Nanostructures: a platform for brain repair and augmentation.Frontiers in systems neuroscience · 2014Review
- rTMS neuromodulation improves electrocortical functional measures of information processing and behavioral responses in autism.Frontiers in systems neuroscience · 2014Article
- Experimental enhancement of neurphysiological function.Frontiers in systems neuroscience · 2014Article
- Functional dynamics of primate cortico-striatal networks during volitional movements.Frontiers in systems neuroscience · 2014Article
- Canonical circuits of the cerebral cortex as enablers of neuroprosthetics.Frontiers in systems neuroscience · 2013Article
- Inter-laminar microcircuits across neocortex: repair and augmentation.Frontiers in systems neuroscience · 2013Article
- Human prefrontal layer II interneurons in areas 46, 10 and 24.Colombia medica (Cali, Colombia)Article
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Authors and funding
7 authors.
Funding
Abstract
During the perception-to-action cycle, our cerebral cortex mediates the interactions between the environment and the perceptual-executive systems of the brain. At the top of the executive hierarchy, prefrontal cortical microcircuits are assumed to bind perceptual and executive control information to guide goal-driven behavior. Here, we tested this hypothesis by comparing simultaneously recorded neuron firing in prefrontal cortical layers and the caudate-putamen of rhesus monkeys, trained in a spatial-versus-object, rule-based match-to-sample task. We found that during the perception and executive selection phases, cell firing in the localized prefrontal layers and caudate-putamen region exhibited similar location preferences on spatial-trials, but less on object- trials. Then, we facilitated the perceptual-executive circuit by stimulating the prefrontal infra-granular-layers with patterns previously derived from supra-granular-layers, and produced stimulation-induced spatial preference in percent correct performance on spatial trials, similar to neural tuning. These results show that inter-laminar prefrontal microcircuits play causal roles to the perception-to-action cycle.
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