ArticleAmerican journal of physiology. Heart and circulatory physiology2013
Modulation of regional dispersion of repolarization and T-peak to T-end interval by the right and left stellate ganglia.
Article in American journal of physiology. Heart and circulatory physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.
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Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Continuous stellate ganglion block for ventricular arrhythmias: case series, systematic review, and differences from thoracic epidural anaesthesia.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Pooled it
- Ventricular repolarization heterogeneity in patients with COVID-19: Original data, systematic review, and meta-analysis.Clinical cardiology · 2022Pooled it
- Efficacy of Stellate Ganglion Blockade in Managing Electrical Storm: A Systematic Review.JACC. Clinical electrophysiology · 2017Pooled it
- Cardiac repolarization and autonomic regulation during short-term cold exposure in hypertensive men: an experimental study.PloS one · 2014Trial
- The utility of the T wave peak to T wave end interval to Q-T end interval ratio as a dynamic indicator of cardiac sympathetic activity: a preliminary study.Heart and vessels · 2026Article
- Differential effects of non-selective and cardio-selective beta-blocker therapy on ECG parameters in long QT syndrome type 1.International journal of cardiology. Heart & vasculature · 2026Article
- Article
- Autonomic dysregulation and atrial arrhythmias.American journal of physiology. Cell physiology · 2025Review
- Elevated serum amylase concentrations are associated with worse in-hospital outcomes among patients with acute myocardial infarction.BMC cardiovascular disorders · 2025Article
- Stellate ganglia stimulation counteracts vagal stimulation by significantly increasing heart rate and blood pressure.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Cardiac sympathetic modulation: searching for a simplified approach.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Cardiac Sympathetic Innervation and Ventricular Arrhythmias in Structural Heart Disease: Current Peripheral Neuromodulation Therapies and Emerging Therapeutic Targets.Arrhythmia & electrophysiology review · 2025Review
- Stellate ganglion blockade for the management of ventricular arrhythmia storm.European heart journal · 2024Article
- Real-time in vivo thoracic spinal glutamate sensing during myocardial ischemia.American journal of physiology. Heart and circulatory physiology · 2023Article
- Thoracic Dorsal Root Ganglion Application of Resiniferatoxin Reduces Myocardial Ischemia-Induced Ventricular Arrhythmias.Biomedicines · 2023Article
- Sympathetic Modulation in Cardiac Arrhythmias: Where We Stand and Where We Go.Journal of personalized medicine · 2023Review
- Thoracic dorsal root ganglion stimulation reduces acute myocardial ischemia induced ventricular arrhythmias.Frontiers in neuroscience · 2023Article
- Autonomic nervous system and cardiac neuro-signaling pathway modulation in cardiovascular disorders and Alzheimer's disease.Frontiers in physiology · 2023Review
- Autonomic imbalance and atrial ectopic activity-a pathophysiological and clinical view.Frontiers in physiology · 2022Review
- Spinal Anesthesia Reduces Myocardial Ischemia-triggered Ventricular Arrhythmias by Suppressing Spinal Cord Neuronal Network Interactions in Pigs.Anesthesiology · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Left stellate or right stellate ganglion stimulation (LGSG or RSGS, respectively) is associated with ventricular tachyarrhythmias; however, the electrophysiological mechanisms remain unclear. We assessed 1) regional dispersion of myocardial repolarization during RSGS and LSGS and 2) regional electrophysiological mechanisms underlying T-wave changes, including T-peak to T-end (Tp-e) interval, which are associated with ventricular tachyarrhythmia/ventricular fibrillation. In 10 pigs, a 56-electrode sock was placed around the heart, and both stellate ganglia were exposed. Unipolar electrograms, to asses activation recovery interval (ARI) and repolarization time (RT), and 12-lead ECG were recorded before and during RSGS and LSGS. Both LSGS and RSGS increased dispersion of repolarization; with LSGS, the greatest regional dispersion occurred on the left ventricular (LV) anterior wall and LV apex, whereas with RSGS, the greatest regional dispersion occurred on the right ventricular posterior wall. Baseline, LSGS, and RSGS dispersion correlated with Tp-e. The increase in RT dispersion, which was due to an increase in ARI dispersion, correlated with the increase in Tp-e intervals (R(2) = 0.92 LSGS; and R(2) = 0.96 RSGS). During LSGS, the ARIs and RTs on the lateral and posterior walls were shorter than the anterior LV wall (P < 0.01) and on the apex versus base (P < 0.05), explaining the T-wave vector shift posteriorly/inferiorly. RSGS caused greater ARI and RT shortening on anterior versus lateral or posterior walls (P < 0.01) and on base versus apex (P < 0.05), explaining the T-wave vector shift anteriorly/superiorly. LSGS and RSGS cause differential effects on regional myocardial repolarization, explaining the ECG T-wave morphology. Sympathetic stimulation, in line with its proarrhythmic effects, increases Tp-e interval, which correlates with increases in myocardial dispersion of repolarization.
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Registered trials
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