Trial reportClinical neuroradiology2014
Mechanical thrombectomy with the penumbra 3D separator and lesional aspiration: technical feasibility and clinical outcome.
Trial report in Clinical neuroradiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Trial
- Stent retrievers for acute ischemic stroke: technological advances, clinical applications, and future perspectives.Journal of neurology · 2026Review
- Innovation and development of stent retrievers in acute ischemic stroke.Frontiers of medicine · 2025Review
- Stentrievers : An engineering review.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023Review
- Rescue of migrated Woven Endobridge devices using a stent-retriever-technique in a porcine model.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2020Article
- Retrieval of Migrated Volume Coils Using Different Clot Retrievers in a Porcine Model.Clinical neuroradiology · 2018Article
- Frontline ADAPT therapy to treat patients with symptomatic M2 and M3 occlusions in acute ischemic stroke: initial experience with the Penumbra ACE and 3MAX reperfusion system.Journal of neurointerventional surgery · 2018Article
- Reperfusion therapy in acute ischemic stroke: dawn of a new era?BMC neurology · 2018Review
- A Case of Acute Isolated Posterior Cerebral Artery Occlusion Successfully Treated with Endovascular Clot Aspiration.NMC case report journal · 2017Article
- Acute Basilar Artery Occlusion with Underlying High-Grade Basilar Artery Stenosis: Multimodal Endovascular Therapy in a Series of Seven Patients.Clinical neuroradiology · 2015Article
- Endovascular stroke therapy at nighttime and on weekends-as fast and effective as during normal business hours?Journal of vascular and interventional neurology · 2015Article
- Endovascular revascularization for basilar artery occlusion.Interventional neurology · 2015Review
- Evolution of endovascular mechanical thrombectomy for acute ischemic stroke.World journal of clinical cases · 2014Review
- Complications of mechanical thrombectomy for acute ischemic stroke-a retrospective single-center study of 176 consecutive cases.Neuroradiology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeIntravenous recombinant human tissue plasminogen activator (IV rtPA) therapy has limited revascularization rates in large artery occlusions. We describe the safety and effectiveness of the self-expanding, fully retrievable Separator 3D device as a component of the Penumbra System in revascularization of large artery occlusion in acute ischemic stroke. The 3D secures thrombus with lesional aspiration and functions by retrieving or debulking the clot. MATERIALS AND
methodsProspective, single-center pilot study of 20 patients with an acute ischemic stroke secondary to a large artery occlusion within 9 h from symptom onset. The occlusion sites were middle cerebral artery in nine patients, internal carotid artery terminus in eight patients, and basilar artery in three patients. Thrombectomy was performed in 18 patients who had previously received IV rtPA, and of these, two patients had prior failed treatment with the Solitaire stent. One patient had prior failed treatment with the Revive stent.
resultsSuccessful revascularization defined by Thrombolysis in Cerebral Infarction grade 2b-3 was achieved in 17 of 20 (85%) treated vessels. The median time from symptom onset to recanalization was 4.4 h (interquartile range 3.8-5.6 h). No procedural complications occurred, and no symptomatic intracranial hemorrhage was observed. Three (15%) patients died. At 90 days, 50% of patients showed good functional outcome (modified Rankin Scale score ≤ 2).
conclusionEarly results suggest that the Separator 3D, which combines a retriever with lesional aspiration, enables safe and effective revascularization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.