ReviewCellular and molecular life sciences : CMLS2014
You are what you eat, and so are your children: the impact of micronutrients on the epigenetic programming of offspring.
Review in Cellular and molecular life sciences : CMLS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Pooled it
- Metformin and insulin exacerbate one-carbon metabolism deficits in pregnant growth restricted rats and impacts the placenta, fetal liver and pancreas.The Journal of physiology · 2025Article
- Maternal exacerbating and protective factors that shape the prevalence and severity of child attention-deficit hyperactivity disorder: a narrative review.Frontiers in psychiatry · 2025Review
- Healthful Eating Behaviors among Couples Contribute to Lower Gestational Weight Gain.Nutrients · 2024Article
- Blood DNA methylation signature of diet quality and association with cardiometabolic traits.European journal of preventive cardiology · 2024Article
- The Effect of Maternal High-Fat Diet on Adipose Tissue Histology and Lipid Metabolism-Related Genes Expression in Offspring Rats.Nutrients · 2024Article
- Micronutrients in early life and offspring metabolic health programming: a promising target for preventing non-communicable diseases.European journal of clinical nutrition · 2023Review
- Methyl Donors, Epigenetic Alterations, and Brain Health: Understanding the Connection.International journal of molecular sciences · 2023Review
- Review
- Effect of Paternal Diet on Spermatogenesis and Offspring Health: Focus on Epigenetics and Interventions with Food Bioactive Compounds.Nutrients · 2022Review
- Dietary Intake and Genetic Background Influence Vitamin Needs during Pregnancy.Healthcare (Basel, Switzerland) · 2022Review
- The Epigenetic Role of Vitamin C in Neurodevelopment.International journal of molecular sciences · 2022Review
- Nutritional Approach to Prevention and Treatment of Cardiovascular Disease in Childhood.Nutrients · 2021Review
- A primer on metabolic memory: why existing diabesity treatments fail.Clinical kidney journal · 2021Review
- Maternal diabetes and obesity influence the fetal epigenome in a largely Hispanic population.Clinical epigenetics · 2020Article
- Physicochemical Foundations of Life that Direct Evolution: Chance and Natural Selection are not Evolutionary Driving Forces.Life (Basel, Switzerland) · 2020Article
- Eating Disorders During Gestation: Implications for Mother's Health, Fetal Outcomes, and Epigenetic Changes.Frontiers in pediatrics · 2020Review
- Paternal preconception folate intake in relation to gestational age at delivery and birthweight of newborns conceived through assisted reproduction.Reproductive biomedicine online · 2019Article
- Dietary patterns are influenced by socio-demographic conditions of women in childbearing age: a cohort study of pregnant women.BMC public health · 2018Article
- Long-Term Health Effects and Underlying Biological Mechanisms of Developmental Exposure to Arsenic.Current environmental health reports · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The research field of fetal programming has developed tremendously over the years and increasing knowledge suggests that both maternal and paternal unbalanced diet can have long-lasting effects on the health of offspring. Studies implicate that macronutrients play an important role in fetal programming, although the importance of micronutrients is also becoming increasingly apparent. Folic acid and vitamins B2, B6 and B12 are essential for one-carbon metabolism and are involved in DNA methylation. They can therefore influence the programming of the offspring's epigenome. Also, other micronutrients such as vitamins A and C, iron, chromium, zinc and flavonoids play a role in fetal programming. Since it is estimated that approximately 78 % of pregnant women in the US take vitamin supplements during pregnancy, more attention should be given to the long-term effects of these supplements on offspring. In this review we address several different studies which illustrate that an unbalanced diet prior and during pregnancy, regarding the intake of micronutrients of both mother and father, can have long-lasting effects on the health of adult offspring.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.