Trial reportSurgical endoscopy2013
Comparison of probe-based confocal endomicroscopy with virtual chromoendoscopy and white-light endoscopy for diagnosis of gastric intestinal metaplasia.
Trial report in Surgical endoscopy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Diagnostic performance of confocal laser endomicroscopy for optical diagnosis of gastric intestinal metaplasia: a meta-analysis.BMC gastroenterology · 2016Pooled it
- Confocal Laser Endomicroscopy in Gastrointestinal and Pancreatobiliary Diseases: A Systematic Review and Meta-Analysis.BioMed research international · 2016Pooled it
- Comparison of white-light endoscopy, optical-enhanced and acetic-acid magnifying endoscopy for detecting gastric intestinal metaplasia: A randomized trial.World journal of clinical cases · 2021Trial
- Predictability of gastric intestinal metaplasia by patchy lavender color seen on linked color imaging endoscopy.Lasers in medical science · 2019Trial
- Value of Magnifying Endoscopy With Narrow-Band Imaging and Confocal Laser Endomicroscopy in Detecting Gastric Cancerous Lesions.Medicine · 2015Trial
- Artificial intelligence assistance improves endoscopist accuracy for gastric cancer dysplasia and intestinal metaplasia.Scientific reports · 2026Article
- Confocal laser endomicroscopy for upper gastrointestinal neoplasia: Systematic review and meta-analysis.Endoscopy international open · 2026Article
- The artificial intelligence revolution in gastric cancer management: clinical applications.Cancer cell international · 2025Review
- The benefits of using confocal laser endomicroscopy in the diagnosis of gastric cancer and precancerous lesions: a case report.Frontiers in oncology · 2025Article
- The role of needle-based confocal laser endomicroscopy in the diagnosis of pancreatic neuroendocrine tumors.Clinical endoscopy · 2024Article
- Review
- Hesitate between confocal laser endomicroscopy and narrow-band imaging: how to choose a better method in the detection of focal precancerous state of gastric cancer.American journal of translational research · 2022Review
- Confocal Laser Endomicroscopy Can Improve the Diagnosis Rate and Range Assessment of Patients With Conflicting Chronic Atrophic Gastritis Results of White Light Endoscopic and Pathological Diagnosis.Frontiers in oncology · 2022Article
- Confocal laser endomicroscopy in gastro-intestinal endoscopy: technical aspects and clinical applications.Translational gastroenterology and hepatology · 2022Review
- SAGES TAVAC safety and efficacy analysis confocal laser endomicroscopy.Surgical endoscopy · 2021Review
- Recent Advances and the Potential for Clinical Use of Autofluorescence Detection of Extra-Ophthalmic Tissues.Molecules (Basel, Switzerland) · 2020Review
- Advanced endoscopic methods in gastrointestinal diseases: a systematic review.Quantitative imaging in medicine and surgery · 2019Review
- Ability of blue laser imaging with magnifying endoscopy for the diagnosis of gastric intestinal metaplasia.Lasers in medical science · 2018Article
- Confocal Laser Endomicroscopy for Diagnosing Malignant Pleural Effusions.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Clinical impact of confocal laser endomicroscopy in the management of gastrointestinal lesions with an uncertain diagnosis.World journal of gastrointestinal endoscopy · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe prospectively compared the diagnostic performance of autofluorescence imaging (AFI), magnifying narrow band imaging (mNBI), and probe-based confocal laser endomicroscopy (pCLE) with white light endoscopy (WLE) for the diagnosis of gastric intestinal metaplasia (GIM), using histology as the "gold standard."
designChinese >50 years old with history of GIM were prospectively recruited. All subjects underwent WLE, followed by AFI and NBI, and finally pCLE. Patients were randomized to undergo either AFI before NBI or vice versa. In each patient, a minimum of six sites (antrum lesser and greater curve, body lesser and greater curve, incisura, cardia, and any lesion) were each examined by WLE, AFI, NBI, and pCLE. The diagnoses were made real-time. Biopsies for histology were taken from all examined sites. pCLE videos also were reviewed off-site. Analysis was performed per-site.
resultsA total of 125 sites in 20 patients were examined. For diagnosing GIM, real-time pCLE had better sensitivity (90.9 vs. 37.9%, p < 0.001) and accuracy (88.0 vs. 64.8%, p < 0.001) compared with WLE. Sensitivity (90.9 vs. 68.2%, p = 0.001), specificity (84.7 vs. 69.5%, p = 0.042), and accuracy (88 vs. 68.8%, p < 0.001) of real-time pCLE were better than AFI. Sensitivity, specificity, and accuracy of real-time pCLE and mNBI for diagnosing GIM were similar. Off-site pCLE had significantly better accuracy for diagnosing GIM compared to WLE, AFI, and mNBI. Off-site pCLE had superior specificity (94.9 vs. 84.7%, p = 0.031) and accuracy (95.2 vs. 88.0%, p = 0.012) compared with real-time pCLE.
conclusionspCLE was superior to AFI and WLE for diagnosing GIM. Off-site review improved performance of pCLE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.