ArticleApplied and environmental microbiology2013
An extracellular Serine/Threonine-rich protein from Lactobacillus plantarum NCIMB 8826 is a novel aggregation-promoting factor with affinity to mucin.
Article in Applied and environmental microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- From One-Size-Fits-All to Precision Medicine: The Promise of Personalized Probiotics.Probiotics and antimicrobial proteins · 2026Review
- Isolation and Characterization of β-Phenylethylamine-Producing Lactic Acid Bacteria from Dairy Products.Microorganisms · 2025Article
- Development of aApplied and environmental microbiology · 2024Article
- Effects ofAnimals : an open access journal from MDPI · 2023Article
- Genome Sequence and Assessment of Safety and Potential Probiotic Traits ofMicroorganisms · 2022Article
- Bistable auto-aggregation phenotype in Lactiplantibacillus plantarum emerges after cultivation in in vitro colonic microbiota.BMC microbiology · 2021Article
- Mucolytic bacteria: prevalence in various pathological diseases.World journal of microbiology & biotechnology · 2021Review
- Molecular identification and in vitro evaluation of probiotic functional properties of some Egyptian lactic acid bacteria and yeasts.Journal, genetic engineering & biotechnology · 2021Article
- Effects of potential synbiotic interaction between Lactobacillus rhamnosus GG and salicylic acid on human colon and prostate cancer cells.Archives of microbiology · 2021Article
- Butanol Tolerance ofGenes · 2021Article
- Paraprobiotics and Postbiotics of ProbioticFrontiers in nutrition · 2020Review
- New insights into the role of plasmids from probiotic Lactobacillus pentosus MP-10 in Aloreña table olive brine fermentation.Scientific reports · 2019Article
- A planarian nidovirus expands the limits of RNA genome size.PLoS pathogens · 2018Article
- Bacterial autoaggregation.AIMS microbiology · 2018Review
- Lactobacillus plantarum WCFS1 and its host interaction: a dozen years after the genome.Microbial biotechnology · 2016Review
- Molecular Players Involved in the Interaction Between Beneficial Bacteria and the Immune System.Frontiers in microbiology · 2015Review
- Lactobacillus gasseri SBT2055 reduces infection by and colonization of Campylobacter jejuni.PloS one · 2014Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoaggregation in lactic acid bacteria is directly related to the production of certain extracellular proteins, notably, aggregation-promoting factors (APFs). Production of aggregation-promoting factors confers beneficial traits to probiotic-producing strains, contributing to their fitness for the intestinal environment. Furthermore, coaggregation with pathogens has been proposed to be a beneficial mechanism in probiotic lactic acid bacteria. This mechanism would limit attachment of the pathogen to the gut mucosa, favoring its removal by the human immune system. In the present paper, we have characterized a novel aggregation-promoting factor in Lactobacillus plantarum. A mutant with a knockout of the D1 gene showed loss of its autoaggregative phenotype and a decreased ability to bind to mucin, indicating an adhesion role of this protein. In addition, heterologous production of the D1 protein or an internal fragment of the protein, characterized by its abundance in serine/threonine, strongly induced autoaggregation in Lactococcus lactis. This result strongly suggested that this internal fragment is responsible for the bioactivity of D1 as an APF. To our knowledge, this is the first report on a gene coding for an aggregation-promoting factor in Lb. plantarum.
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