ArticleApplied and environmental microbiology2013
Multilocus sequence typing reveals evidence of homologous recombination linked to antibiotic resistance in the genus Salinispora.
Article in Applied and environmental microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Mode of action guided metagenomic natural product discovery reveals convergent evolution of a ClpP-targeting motif.Nature communications · 2026Article
- FunARTS, the Fungal bioActive compound Resistant Target Seeker, an exploration engine for target-directed genome mining in fungi.Nucleic acids research · 2023Article
- SYN-View: A Phylogeny-Based Synteny Exploration Tool for the Identification of Gene Clusters Linked to Antibiotic Resistance.Molecules (Basel, Switzerland) · 2020Article
- Marine Sediment RecoveredPolish journal of microbiology · 2020Article
- ARTS 2.0: feature updates and expansion of the Antibiotic Resistant Target Seeker for comparative genome mining.Nucleic acids research · 2020Article
- Patterns of inter- and intrasubspecific homologous recombination inform eco-evolutionary dynamics of Xylella fastidiosa.The ISME journal · 2019Article
- Detecting and prioritizing biosynthetic gene clusters for bioactive compounds in bacteria and fungi.Applied microbiology and biotechnology · 2019Review
- Genomic divergence and cohesion in a species of pelagic freshwater bacteria.BMC genomics · 2017Article
- The Antibiotic Resistant Target Seeker (ARTS), an exploration engine for antibiotic cluster prioritization and novel drug target discovery.Nucleic acids research · 2017Article
- Phylogenomic Insight into Salinispora (Bacteria, Actinobacteria) Species Designations.Scientific reports · 2017Article
- Prioritizing Natural Product Diversity in a Collection of 146 Bacterial Strains Based on Growth and Extraction Protocols.Journal of natural products · 2017Article
- Effects of Actinomycete Secondary Metabolites on Sediment Microbial Communities.Applied and environmental microbiology · 2017Article
- Natural Products and the Gene Cluster Revolution.Trends in microbiology · 2016Review
- Competitive strategies differentiate closely related species of marine actinobacteria.The ISME journal · 2016Article
- The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery.Natural product reports · 2015Review
- Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species.Chemistry & biology · 2015Article
- Direct capture and heterologous expression of Salinispora natural product genes for the biosynthesis of enterocin.Journal of natural products · 2015Article
- Population genetic analysis of Streptomyces albidoflavus reveals habitat barriers to homologous recombination in the diversification of streptomycetes.Applied and environmental microbiology · 2015Article
- Exploring the diversity and metabolic potential of actinomycetes from temperate marine sediments from Newfoundland, Canada.Journal of industrial microbiology & biotechnology · 2015Article
- Involvement of aph(3')-IIa in the formation of mosaic aminoglycoside resistance genes in natural environments.Frontiers in microbiology · 2015Article
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3 authors.
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Abstract
The three closely related species that currently comprise the genus Salinispora were analyzed using a multilocus sequence typing approach targeting 48 strains derived from four geographic locations. Phylogenetic congruence and a well-supported concatenated tree provide strong support for the delineation of the three species as currently described and the basal relationship of Salinispora arenicola to the more recently diverged sister taxa S. tropica and S. pacifica. The phylogeny of the initial region of the rpoB gene sequenced was atypical, placing the related genera Micromonospora and Verrucosispora within the Salinispora clade. This phylogenetic incongruence was subsequently ascribed to a homologous-recombination event in a portion of the gene associated with resistance to compounds in the rifamycin class, which target RpoB. All S. arenicola strains produced compounds in this class and possessed resistance-conferring amino acid changes in RpoB. The phylogeny of a region of the rpoB gene that is not associated with rifamycin resistance was congruent with the other housekeeping genes. The link between antibiotic resistance and homologous recombination suggests that incongruent phylogenies provide opportunities to identify the molecular targets of secondary metabolites, an observation with potential relevance for drug discovery efforts. Low ratios of interspecies recombination to mutation, even among cooccurring strains, coupled with high levels of within-species recombination suggest that the three species have been described in accordance with natural barriers to recombination.
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