ArticleApplied and environmental microbiology2013
Molecular typing of CTX-M-producing escherichia coli isolates from environmental water, swine feces, specimens from healthy humans, and human patients.
Article in Applied and environmental microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 4 of them syntheses that pooled it.
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Who cites it
54 citing papers in PubMed, 4 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Antibiotic resistance of fecal carriage of Escherichia coli from pig farms in China: a meta-analysis.Environmental science and pollution research international · 2022Pooled it
- Global Extraintestinal Pathogenic Escherichia coli (ExPEC) Lineages.Clinical microbiology reviews · 2019Pooled it
- Are Food Animals Responsible for Transfer of Antimicrobial-Resistant Escherichia coli or Their Resistance Determinants to Human Populations? A Systematic Review.Foodborne pathogens and disease · 2018Pooled it
- Epidemic potential of Escherichia coli ST131 and Klebsiella pneumoniae ST258: a systematic review and meta-analysis.BMJ open · 2016Pooled it
- Megaplasmids associate withbioRxiv : the preprint server for biology · 2025Article
- First national study on genomic profiling ofEnvironmental challenges (Amsterdam, Netherlands) · 2025Article
- A systematic review of antimicrobial resistance transmission inferences at the human-livestock interface in Africa.npj antimicrobials and resistance · 2025Article
- Characterization of multidrug-resistant Escherichia coli isolated from clinical (UPEC) and environmental samples.Molecular biology reports · 2025Article
- Characterization of antibiotic determinants and heavy metal resistance genes inMicrobial genomics · 2025Article
- Epidemiological and molecular characteristics of extraintestinal pathogenic escherichia coli isolated from diseased cattle and sheep in Xinjiang, China from 2015 to 2019.BMC veterinary research · 2025Article
- Isolation and Characterization of Extended-Spectrum β-Lactamase ProducingIndian journal of microbiology · 2024Article
- Current epidemiologic features and health dynamics of ESBL-producingBiosafety and health · 2024Review
- Molecular Characterization and Prevalence of Antimicrobial-ResistantMicroorganisms · 2023Article
- Article
- World Health Organization critical priorityFrontiers in microbiology · 2022Article
- Prevalence of Multidrug-Resistant CTX-M Extended Spectrum Beta-Lactamase-ProducingFrontiers in veterinary science · 2022Article
- Prevalence and risk analysis of mobile colistin resistance and extended-spectrumEmerging microbes & infections · 2021Article
- Dynamics of extended-spectrum beta-lactamase-producingMicrobial genomics · 2021Article
- Article
- Assessment of the Presence of Resistance Genes Detected from the Environment and Selected Food Products in Benin.Journal of environmental and public health · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CTX-M-producing Escherichia coli is the predominant type of extended-spectrum β-lactamase (ESBL)-producing E. coli worldwide. In this study, molecular typing was conducted for 139 CTX-M-producing E. coli isolates, phenotypically positive for ESBLs, isolated from environmental water, swine, healthy humans, and hospitalized patients in Hangzhou, China. The antibiotic resistance profiles of the isolates for the cephalosporins and fluoroquinolones were determined. The isolates showed 100% resistance to cefotaxime and ceftriaxone while maintaining relatively high susceptibility to cefoxitin, cefepime, and ceftazidime. A total of 61.9% (86/139) of the isolates, regardless of origin, showed high resistance to fluoroquinolones. PCRs and DNA sequencing indicated that blaCTX-M-14 was the most prevalent CTX-M-9 group gene and that blaCTX-M-15 and blaCTX-M-55 were the dominant CTX-M-1 group genes. Isolates from all sources with CTX-M types belonging to the CTX-M-1 or CTX-M-9 group were most frequently associated with epidemics. Molecular homology analysis of the isolates, conducted by phylogenetic grouping, pulsed-field gel electrophoresis (PFGE), and multilocus sequence typing (MLST), demonstrated that the dominant clones belonged to B2-ST131, D-ST648, D-ST38, or A-CC10. These four sequence types (STs) were discovered in E. coli isolates both from humans and from environmental water, suggesting frequent and continuous intercompartment transmission between humans and the aquatic environment. Seven novel sequence types were identified in the current study. In conclusion, this study is the first to report the molecular homology analysis of CTX-M-producing E. coli isolates collected from water, swine, and healthy and hospitalized humans, suggesting that pathogens in the environment might originate both from humans and from animals.
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