ArticleNature neuroscience2013
Toll-6 and Toll-7 function as neurotrophin receptors in the Drosophila melanogaster CNS.
Article in Nature neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 117 citations in OpenAlex.
- The neurotrophin DNT-2 via the Toll-2 receptor regulates neuronal survival and morphology during visual system development.Biology open · 2026Article
- Toll receptors mediate tissue intrinsic surveillance against aberrant cells by detecting cell fate aberrations.Development (Cambridge, England) · 2026Article
- Adipose tissue-secreted Spz5 promotes distal tumor progression via Toll-6-mediated Hh pathway activation in Drosophila.The EMBO journal · 2025Article
- AcMNPV, a viral insecticide of Lepidoptera pests, stimulates the immune response of the natural enemyApplied and environmental microbiology · 2025Article
- Chromosome-Level Genome Assembly of the Leafcutter Bee Megachile rotundata Reveals Its Ecological Adaptation and Pollination Biology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Repulsive interactions instruct synaptic partner matching in an olfactory circuit.Research square · 2025Article
- Toll-1-dependent immune evasion induced by fungal infection leads to cell loss in the Drosophila brain.PLoS biology · 2025Article
- The molecular toll pathway repertoire in anopheline mosquitoes.Developmental and comparative immunology · 2025Article
- A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit.eLife · 2024Article
- The Molecular Toll Pathway Repertoire in Anopheline Mosquitoes.bioRxiv : the preprint server for biology · 2024Article
- Maintaining Toll signaling iniScience · 2024Article
- Striped Expression of Leucine-Rich Repeat Proteins Coordinates Cell Intercalation and Compartment Boundary Formation in the EarlySymmetry · 2023Article
- Systematic analysis of the Frazzled receptor interactome establishes previously unreported regulators of axon guidance.Development (Cambridge, England) · 2023Article
- Review
- Innate Immune Response ofInternational journal of molecular sciences · 2023Article
- Article
- Molecular Logic of Synaptic Diversity BetweenbioRxiv : the preprint server for biology · 2023Article
- Review
- Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti.Nature communications · 2022Article
- Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Neurotrophin receptors corresponding to vertebrate Trk, p75(NTR) or Sortilin have not been identified in Drosophila, thus it is unknown how neurotrophism may be implemented in insects. Two Drosophila neurotrophins, DNT1 and DNT2, have nervous system functions, but their receptors are unknown. The Toll receptor superfamily has ancient evolutionary origins and a universal function in innate immunity. Here we show that Toll paralogs unrelated to the mammalian neurotrophin receptors function as neurotrophin receptors in fruit flies. Toll-6 and Toll-7 are expressed in the CNS throughout development and regulate locomotion, motor axon targeting and neuronal survival. DNT1 (also known as NT1 and spz2) and DNT2 (also known as NT2 and spz5) interact genetically with Toll-6 and Toll-7, and DNT1 and DNT2 bind to Toll-6 and Toll-7 promiscuously and are distributed in vivo in domains complementary to or overlapping with those of Toll-6 and Toll-7. We conclude that in fruit flies, Tolls are not only involved in development and immunity but also in neurotrophism, revealing an unforeseen relationship between the neurotrophin and Toll protein families.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.