ArticleParasitology research2013
A rat model to study Blastocytis subtype 1 infections.
Article in Parasitology research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Extracellular vesicles in intestinal protozoa: hidden mediators of host-parasite communication.Gut pathogens · 2025Review
- Colonization with ubiquitous protist Blastocystis ST1 ameliorates DSS-induced colitis and promotes beneficial microbiota and immune outcomes.NPJ biofilms and microbiomes · 2023Article
- Exosomes secreted byFrontiers in medicine · 2022Article
- Historical contingency, geography and anthropogenic patterns of exposure drive the evolution of host switching in theParasitology · 2021Article
- Article
- Article
- Children of Senegal River Basin show the highest prevalence of Blastocystis sp. ever observed worldwide.BMC infectious diseases · 2014Article
- Article
- Update on the pathogenic potential and treatment options for Blastocystis sp.Gut pathogens · 2014Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blastocytis sp. is the most common enteric protozoan in human, but its pathogenesis is still unclear. To study the infectious effects of Blastocytis sp. on tissue damage, we orally challenged the Sprague Dawley (SD) rats with different doses of Blastocytis subtype1 (ST1) and examined the histological changes. We found that there was no difference of disease incidence among the Blastocytis ST1-infected groups challenged with different doses of the protozoan. Histological results showed that the lamina propria was infected by Blastocytis ST1 in the vacuolar form, along with the mucus membrane slough and inflammatory cell infiltration into the lamina propria. Compared to the uninfected group, the histological scores were significantly higher in the infected groups. However, groups infected with various doses of Blastocystis ST1 showed no difference in terms of histological scores. In conclusion, this study indicates that the SD rats can be easily infected with Blastocytis ST1 even with low dose of cysts, and the histopathological effects of the infection in the intestine of the infected rats show individual differences.
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