Evidence map›Paper›PMID 23892241›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2013

Pooled HIV-1 viral load testing using dried blood spots to reduce the cost of monitoring antiretroviral treatment in a resource-limited setting.

Pieter Pannus, Emmanuel Fajardo, Carol Metcalf, Rebecca M Coulborn, Laura T Durán, Helen Bygrave, Tom Ellman, Daniela Garone, Michael Murowa, Reuben Mwenda and 2 more

Abstract readEvaluation Study
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Interferon-γ-Inducible Protein 10 (IP-10) as a Screening Tool to Optimize Human Immunodeficiency Virus RNA Monitoring in Resource-Limited Settings.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017
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  11. Scale-up of Routine Viral Load Testing in Resource-Poor Settings: Current and Future Implementation Challenges.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Pieter Pannus*Médecins Sans Frontières, Southern Africa Medical Unit, Cape Town, South Africa; †Médecins Sans Frontières, Thyolo, Malawi; ‡Ministry of Health, Health Technical Support Services, Diagnostics, District Management Office, Thyolo, Malawi; §Ministry of Health, Lilongwe, Malawi; ‖Médecins Sans Frontières, Operational Research Unit, Brussels, Belgium; and ¶Division of Medical Virology, Stellenbosch University, and National Health Laboratory Service, Tygerberg, South Africa.
Emmanuel Fajardo
Carol Metcalf
Rebecca M Coulborn
Laura T Durán
Helen Bygrave
Tom Ellman
Daniela Garone
Michael Murowa
Reuben Mwenda
Tony Reid
Wolfgang Preiser

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rollout of routine HIV-1 viral load monitoring is hampered by high costs and logistical difficulties associated with sample collection and transport. New strategies are needed to overcome these constraints. Dried blood spots from finger pricks have been shown to be more practical than the use of plasma specimens, and pooling strategies using plasma specimens have been demonstrated to be an efficient method to reduce costs. This study found that combination of finger-prick dried blood spots and a pooling strategy is a feasible and efficient option to reduce costs, while maintaining accuracy in the context of a district hospital in Malawi.

Indexed as

Viral LoadAdultAnti-HIV AgentsDeveloping CountriesDried Blood Spot TestingDrug MonitoringFemaleHIV-1HIV InfectionsHumansMalawiMaleMiddle AgedReproducibility of ResultsRNA, ViralAnti-HIV AgentsRNA, Viral

Identifiers

PMID23892241
PMCPMC3815087

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.