Evidence map›Paper›PMID 23892057›Full record

ArticleDevelopmental and comparative immunology2013

Characterization and allelic variation of the transporters associated with antigen processing (TAP) genes in the domestic dog (Canis lupus familiaris).

Gregory S Gojanovich, Peter Ross, Savannah G Holmer, Jennifer C Holmes, Paul R Hess

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental and comparative immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Gregory S GojanovichImmunology Program, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.
Peter Ross
Savannah G Holmer
Jennifer C Holmes
Paul R Hess
North Carolina State University · US

Funding

Effect of Ag-specific CD8+ T cell deletion on diabetogenesis in the NOD mouseK08DK082264 · NIDDK · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI HESS, PAUL R · 2008 to 2011
$490k
NIDDK NIH HHS DK082264NIDDK NIH HHS K08 DK082264
6 · The paper itself

Abstract

The function of the transporters associated with antigen processing (TAP) complex is to shuttle antigenic peptides from the cytosol to the endoplasmic reticulum to load MHC class I molecules for CD8(+) T-cell immunosurveillance. Here we report the promoter and coding regions of the canine TAP1 and TAP2 genes, which encode the homologous subunits forming the TAP heterodimer. By sampling genetically divergent breeds, polymorphisms in both genes were identified, although there were few amino acid differences between alleles. Splice variants were also found. When aligned to TAP genes of other species, functional regions appeared conserved, and upon phylogenetic analysis, canine sequences segregated appropriately with their orthologs. Transfer of the canine TAP2 gene into a murine TAP2-defective cell line rescued surface MHC class I expression, confirming exporter function. This data should prove useful in investigating the association of specific TAP defects or alleles with immunity to intracellular pathogens and cancer in dogs.

Indexed as

AllelesAmino Acid SequenceAnimalsAntigen PresentationATP-Binding Cassette TransportersCell LineDogsGenetic VariationHistocompatibility Antigens Class IHumansMiceMolecular Sequence DataPhylogenyPromoter Regions, GeneticProtein IsoformsWolvesATP-Binding Cassette TransportersHistocompatibility Antigens Class IProtein IsoformsAbABCAllelesantibodyATP-binding cassetteCanineCDSCLcode determining sequencecytosolic loopDLAdog leukocyte antigenESTexpressed sequence taggamma activating sequenceGASGFPgreen fluorescent proteinHLAhuman leukocyte antigenIFNIFN-stimulated response elementIFRImmunologyinterferoninterferon regulatory factorISREMED1multiple start site element downstream1NBDnucleotide-binding domainopen reading frameORFPBMCperipheral blood mononuclear cellsPKRprotein kinase RRLM-RACERNA ligase-mediated rapid amplification of cDNA endssignal transducers and activators of transcriptionsingle nucleotide polymorphismSNPsplice variantSplice variantsSTATSVTAPTMDtranscription start sitetransmembrane domaintransporter associated with antigen processingTransporter associated with antigen processingTSSuntranslated regionUTRβ2Mβ2-microglobulin

Identifiers

PMID23892057
PMCPMC3846772
OpenAlexW2034369047

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.