ArticleReproductive toxicology (Elmsford, N.Y.)2013
Trace elements and endometriosis: the ENDO study.
Article in Reproductive toxicology (Elmsford, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- From Environmental to Possible Occupational Exposure to Risk Factors: What Role Do They Play in the Etiology of Endometriosis?International journal of environmental research and public health · 2021Pooled it
- Pooled it
- Pooled it
- Dietary and Environmental Exposure to Toxic Elements in Endometriosis: A Missing Piece of the Etiological Puzzle?Nutrients · 2026Review
- Ionomics powered single-cell mapping reveals targetable iron dysregulation in endometriosis associated macrophages.BMC medicine · 2026Article
- The Role of Antioxidant Minerals in the Pathophysiology and Treatment of Endometriosis-Systematic Review.Antioxidants (Basel, Switzerland) · 2025Review
- The Combined Effects of Urine Zinc, Cadmium, Mercury, Lead, and Copper on Endometrial Cancer Staging.International journal of environmental research and public health · 2025Article
- Association between urinary arsenic and the prevalence of endometriosis in women in the United States.Frontiers in public health · 2025Article
- Exploring the link between dietary zinc intake and endometriosis risk: insights from a cross-sectional analysis of American women.BMC public health · 2024Article
- How Can Selected Dietary Ingredients Influence the Development and Progression of Endometriosis?Nutrients · 2024Review
- Copper in Gynecological Diseases.International journal of molecular sciences · 2023Review
- Urinary cadmium and endometriosis prevalence in a US nationally representative sample: results from NHANES 1999-2006.Human reproduction (Oxford, England) · 2023Article
- The copper chelator ammonium tetrathiomolybdate inhibits the progression of experimental endometriosis in TNFR1-deficient mice.Scientific reports · 2023Article
- Identification of a Novel Cuproptosis-Related Gene Signature in Eutopic Endometrium of Women with Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Review
- Brief Review of Endometriosis and the Role of Trace Elements.International journal of molecular sciences · 2021Review
- Does Exposure of Lead and Cadmium Affect the Endometriosis?International journal of environmental research and public health · 2021Article
- Environmental risk factors for endometriosis: A critical evaluation of studies and recommendations from the epidemiologic perspective.Current epidemiology reports · 2020Article
- The Cumulative Risk of Chemical and Nonchemical Exposures on Birth Outcomes in Healthy Women: The Fetal Growth Study.International journal of environmental research and public health · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
There has been limited study of trace elements and endometriosis. Using a matched cohort design, 473 women aged 18-44 years were recruited into an operative cohort, along with 131 similarly aged women recruited into a population cohort. Endometriosis was defined as surgically visualized disease in the operative cohort, and magnetic resonance imaging diagnosed disease in the population cohort. Twenty trace elements in urine and three in blood were quantified using inductively coupled plasma mass spectrometry. Logistic regression estimated the adjusted odds (aOR) of endometriosis diagnosis for each element by cohort. No association was observed between any element and endometriosis in the population cohort. In the operative cohort, blood cadmium was associated with a reduced odds of diagnosis (aOR=0.55; 95% CI: 0.31, 0.98), while urinary chromium and copper reflected an increased odds (aOR=1.97; 95% CI: 1.21, 3.19; aOR=2.66; 95% CI: 1.26, 5.64, respectively). The varied associations underscore the need for continued research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.