ArticleDevelopmental biology2013
Enhanced BMP signaling prevents degeneration and leads to endochondral ossification of Meckel's cartilage in mice.
Article in Developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- TGF-β/BMP signaling in skeletal biology: molecular mechanisms, regulatory networks, and therapeutic implications in development, regeneration, and disease.Bone research · 2026Review
- The association of polymorphisms inSaudi journal of biological sciences · 2022Article
- The effects of altered BMP4 signaling in first branchial-arch-derived murine embryonic orofacial tissues.International journal of oral science · 2021Article
- Bone morphogenetic protein induces bone invasion of melanoma by epithelial-mesenchymal transition via the Smad1/5 signaling pathway.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- The Mandibular and Hyoid Arches-From Molecular Patterning to Shaping Bone and Cartilage.International journal of molecular sciences · 2021Review
- NOTCH Signaling Controls Ciliary Body Morphogenesis and Secretion by Directly Regulating Nectin Protein Expression.Cell reports · 2021Article
- LGRs in Skeletal Tissues: An Emerging Role for Wnt-Associated Adult Stem Cell Markers in Bone.JBMR plus · 2020Review
- Diverse Fate of an Enigmatic Structure: 200 Years of Meckel's Cartilage.Frontiers in cell and developmental biology · 2020Review
- Conditional deletion of Bmp2 in cranial neural crest cells recapitulates Pierre Robin sequence in mice.Cell and tissue research · 2019Article
- The Forgotten Skeletogenic Condensations: A Comparison of Early Skeletal Development Amongst Vertebrates.Journal of developmental biology · 2019Review
- Regulatory mechanisms of jaw bone and tooth development.Current topics in developmental biology · 2019Review
- TGF-β Family Signaling in Mesenchymal Differentiation.Cold Spring Harbor perspectives in biology · 2018Review
- Meckel's cartilage breakdown offers clues to mammalian middle ear evolution.Nature ecology & evolution · 2017Article
- A new developmental mechanism for the separation of the mammalian middle ear ossicles from the jaw.Proceedings. Biological sciences · 2017Article
- The Role of Sonic Hedgehog in Craniofacial Patterning, Morphogenesis and Cranial Neural Crest Survival.Journal of developmental biology · 2016Review
- Common mechanisms in development and disease: BMP signaling in craniofacial development.Cytokine & growth factor reviews · 2016Review
- Evolution and functional significance of derived sternal ossification patterns in ornithothoracine birds.Journal of evolutionary biology · 2015Article
- Mandible and Tongue Development.Current topics in developmental biology · 2015Review
- The non-canonical BMP and Wnt/β-catenin signaling pathways orchestrate early tooth development.Development (Cambridge, England) · 2015Article
- Col2CreER(T2), a mouse model for a chondrocyte-specific and inducible gene deletion.European cells & materials · 2014Review
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Meckel's cartilage is a transient supporting tissue of the embryonic mandible in mammals, and disappears by taking different ultimate cell fate along the distal-proximal axis, with the majority (middle portion) undergoing degeneration and chondroclastic resorption. While a number of factors have been implicated in the degeneration and resorption processes, signaling pathways that trigger this degradation are currently unknown. BMP signaling has been implicated in almost every step of chondrogenesis. In this study, we used Noggin mutant mice as a model for gain-of-BMP signaling function to investigate the function of BMP signaling in Meckel's cartilage development, with a focus on the middle portion. We showed that Bmp2 and Bmp7 are expressed in early developing Meckels' cartilage, but their expression disappears thereafter. In contrast, Noggin is expressed constantly in Meckel's cartilage throughout the entire gestation period. In the absence of Noggin, Meckel's cartilage is significantly thickened attributing to dramatically elevated cell proliferation rate associated with enhanced phosphorylated Smad1/5/8 expression. Interestingly, instead of taking a degeneration fate, the middle portion of Meckel's cartilage in Noggin mutants undergoes chondrogenic differentiation and endochondral ossification contributing to the forming mandible. Chondrocyte-specific expression of a constitutively active form of BMPRIa but not BMPRIb leads to enlargement of Meckel's cartilage, phenocopying the consequence of Noggin deficiency. Our results demonstrate that elevated BMP signaling prevents degeneration and leads to endochondral ossification of Meckel's cartilage, and support the idea that withdrawal of BMP signaling is required for normal Meckel's cartilage development and ultimate cell fate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.