Evidence map›Paper›PMID 23891755›Full record

ReviewNeuroscience2013

Neural processing of itch.

Tasuku Akiyama, E Carstens

Abstract readReview
In one paragraph

Review in Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Oral H1 antihistamines as 'add-on' therapy to topical treatment for eczema.The Cochrane database of systematic reviews · 2019
    Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Mechanisms of Itch in Atopic Dermatitis.Juntendo medical journal · 2025
    Review
  11. Neuroimmune recognition of allergens.Current opinion in immunology · 2024
    Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Incidence and Risk Factors for Pruritus in Patients with Nondialysis CKD.Clinical journal of the American Society of Nephrology : CJASN · 2023
    Article
  17. Article
  18. Footedness for scratching itchy eyes in rodents.Proceedings. Biological sciences · 2022
    Article
  19. Article
  20. Article

54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tasuku AkiyamaUniversity of California, Davis, Department of Neurobiology, Physiology & Behavior, 1 Shields Avenue, Davis, CA 95616, United States.
E Carstens

Funding

Spinal mechanisms of itchR01AR057194 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CARSTENS, EARL E · 2009 to 2019
$3.4M
Trigeminal Mechanisms of Oral IrritationR01DE013685 · NIDCR · UNIVERSITY OF CALIFORNIA DAVIS · PI CARSTENS, EARL E · 2001 to 2009
$2.1M
Warmth enhancement of itch via TRPV4R00AR063228 · NIAMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI AKIYAMA, TASUKU · 2014 to 2016
$705k
Rodent model to distinguish between facial itch and painR21DE021183 · NIDCR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CARSTENS, EARL E · 2010 to 2011
$343k
Warmth enhancement of itch via TRPV4K99AR063228 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI AKIYAMA, TASUKU · 2013 to 2014
$176k
NIAMS NIH HHS AR057194NIAMS NIH HHS AR063228NIAMS NIH HHS K99 AR063228NIAMS NIH HHS R00 AR063228NIAMS NIH HHS R01 AR057194NIDCR NIH HHS DE013685NIDCR NIH HHS R01 DE013685NIDCR NIH HHS R21 DE021183
6 · The paper itself

Abstract

While considerable effort has been made to investigate the neural mechanisms of pain, much less effort has been devoted to itch, at least until recently. However, itch is now gaining increasing recognition as a widespread and costly medical and socioeconomic issue. This is accompanied by increasing interest in the underlying neural mechanisms of itch, which has become a vibrant and rapidly-advancing field of research. The goal of the present forefront review is to describe the recent progress that has been made in our understanding of itch mechanisms.

Indexed as

Analgesics, OpioidAnimalsDisease Models, AnimalElectrophysiological PhenomenaHumansInterneuronsNeurons, AfferentNeurotransmitter AgentsPruritusSignal TransductionSpinal CordTrigeminal NerveAnalgesics, OpioidNeurotransmitter Agents5-HT5-HT25-HT receptor subtype 25-hydroxytryptamine (serotonin)AITCallyl isothiocyanateBAM8–22BLTbovine adrenal medullary peptide 8–22dorsal root ganglionDRGendothelin-1endothelin receptor A-1ET-1ETA-1Gastrin-releasing peptideGastrin-releasing peptide receptorG protein-coupled bile acid receptor 1 (GPBAR1)GRPGRPRH1Rhistamine receptor-1IB4IL-31Interleukin 31isolectin B4itchK2PKvleukotriene B4long-term potentiationlow thresholdlow-threshold mechanoreceptorsLPALTLTB4LTB4 receptorLTMRsLTPlysophosphatidic acidMas-related G-protein-coupled receptormechanically insensitiveMIMOR1Dmorphine receptor-1D isoformMrgprnatriuretic peptide receptor Anatriuretic polypeptide Bnerve growth factorneurokinin-1 receptorNGFNK-1nociceptive specificNppbNpraNSoncostatin M receptorOSMRPAFPAGPARperiaqueductal grayPlatelet-activating factorprotease-activated receptorpruritogenspruritusRho-associated protein kinaseRho-ROCKscratching behaviorSPSPCsphingosylphosphorylcholinespinal cordspinothalamic tractSTTsubstance Ptesticular orphan nuclear receptor-4TGR5thromboxane A2TLR3TLR7toll-like receptor 3toll-like receptor 7TR4transient receptor potential ankyrin 1transient receptor potential vanilloid 1trigeminal caudalistrigeminal subnucleus caudalisTRPA1TRPV1two-pore-domain potassium channelsTXA2Vcvesicular glutamate transporter-2VGLUT2voltage-gated potassium channelWDRwide dynamic range

Identifiers

PMID23891755
PMCPMC3772667

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.