ReviewNeuropharmacology2014
Imaging opioid analgesia in the human brain and its potential relevance for understanding opioid use in chronic pain.
Review in Neuropharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 56 citations in OpenAlex.
- Efficacy of Low-Dose Intravenous Ketamine With Spinal Anesthesia for Postoperative Pain Control in Total Knee Arthroplasty: A Randomized Clinical Trial.Pain research & management · 2026Trial
- Stress-Related Brain Alterations in Chronic Pain.European journal of pain (London, England) · 2025Article
- Prenatal opioid exposure alters pain perception and increases long-term health risks in infants with neonatal opioid withdrawal syndrome.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Trends in Physiotherapy of Chronic Low Back Pain Research: Knowledge Synthesis Based on Bibliometric Analysis.Healthcare (Basel, Switzerland) · 2024Review
- Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders.Molecular psychiatry · 2024Article
- Neuroimaging of opioid effects in humans across conditions of acute administration, chronic pain therapy, and opioid use disorder.Trends in neurosciences · 2024Review
- Individuals With Prior Chronic Pain and Long-Term Opioid Treatment May Experience Persistence of That Pain Even After Subsequent Complete Cervical Spinal Cord Injury: Suggestions From a Prospective Case-Controlled Study.Archives of rehabilitation research and clinical translation · 2024Article
- Pain suffering and the self. An active allostatic inference explanation.Neuroscience of consciousness · 2024Article
- Digital Biomarker Applications Across the Spectrum of Opioid Use Disorder.Cogent mental health · 2023Article
- Noncoding RNAs: Novel Targets for Opioid Tolerance.Current neuropharmacology · 2023Review
- Thalamocortical circuits drive remifentanil-induced postoperative hyperalgesia.The Journal of clinical investigation · 2022Article
- An Investigation into Proteomic Constituents of Cerebrospinal Fluid in Patients with Chronic Peripheral Neuropathic Pain Medicated with Opioids- a Pilot Study.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021Article
- Neocortical circuits in pain and pain relief.Nature reviews. Neuroscience · 2021Review
- Suppression of neuropathic pain and comorbidities by recurrent cycles of repetitive transcranial direct current motor cortex stimulation in mice.Scientific reports · 2021Article
- Pain Asymbolia as Depersonalization for Pain Experience. An Interoceptive Active Inference Account.Frontiers in psychology · 2020Article
- Response to "Treating patients rather than their functional neuroimages" (Br J Anaesth 2018; 121: 969-71).British journal of anaesthesia · 2019Article
- The conundrum of opioid tapering in long-term opioid therapy for chronic pain: A commentary.Substance abuse · 2018Article
- Reward Circuitry Plasticity in Pain Perception and Modulation.Frontiers in pharmacology · 2017Review
- Next-generation sequencing of human opioid receptor genes based on a custom AmpliSeq™ library and ion torrent personal genome machine.Clinica chimica acta; international journal of clinical chemistry · 2016Article
- Abuse-Deterrent Opioid Formulations: Pharmacokinetic and Pharmacodynamic Considerations.Clinical pharmacokinetics · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Opioids play an important role for the management of acute pain and in palliative care. The role of long-term opioid therapy in chronic non-malignant pain remains unclear and is the focus of much clinical research. There are concerns regarding analgesic tolerance, paradoxical pain and issues with dependence that can occur with chronic opioid use in the susceptible patient. In this review, we discuss how far human neuroimaging research has come in providing a mechanistic understanding of pain relief provided by opioids, and suggest avenues for further studies that are relevant to the management of chronic pain with opioids. This article is part of the Special Issue Section entitled 'Neuroimaging in Neuropharmacology'.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.