ArticleStructure (London, England : 1993)2013
Subunit folds and maturation pathway of a dsRNA virus capsid.
Article in Structure (London, England : 1993), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 55 citations in OpenAlex.
- Insights into the AAV packaging mechanism: Cryo-EM Structure of the AAV2 Rep-Capsid Packaging Complex.bioRxiv : the preprint server for biology · 2025Article
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- Structure of the RNA-dependent RNA polymerase P2 from the cystovirus φ8.Scientific reports · 2024Article
- Maturation of Viruses.Sub-cellular biochemistry · 2024Review
- Review
- Review
- Review
- Heterologous RNA Recombination in the Cystoviruses φ6 and φ8: A Mechanism of Viral Variation and Genome Repair.Viruses · 2022Review
- RNA Packaging in theInternational journal of molecular sciences · 2022Review
- Cryo-electron Microscopy Structure, Assembly, and Mechanics Show Morphogenesis and Evolution of Human Picobirnavirus.Journal of virology · 2020Article
- Cryo-electron microscopy for the study of virus assembly.Nature chemical biology · 2020Review
- Structural puzzles in virology solved with an overarching icosahedral design principle.Nature communications · 2019Article
- Half a Century of Research on Membrane-Containing Bacteriophages: Bringing New Concepts to Modern Virology.Viruses · 2019Review
- Capsid Structure of dsRNA Fungal Viruses.Viruses · 2018Review
- Component tree analysis of cystovirus φ6 nucleocapsid Cryo-EM single particle reconstructions.PloS one · 2018Article
- Negative charge and membrane-tethered viral 3B cooperate to recruit viral RNA dependent RNA polymerase 3DScientific reports · 2017Article
- Acquisition of functions on the outer capsid surface during evolution of double-stranded RNA fungal viruses.PLoS pathogens · 2017Article
- Cystoviral RNA-directed RNA polymerases: Regulation of RNA synthesis on multiple time and length scales.Virus research · 2017Review
- Double-stranded RNA virus outer shell assembly by bona fide domain-swapping.Nature communications · 2017Article
- Heterodimers as the Structural Unit of the T=1 Capsid of the Fungal Double-Stranded RNA Rosellinia necatrix Quadrivirus 1.Journal of virology · 2016Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
The cystovirus ϕ6 shares several distinct features with other double-stranded RNA (dsRNA) viruses, including the human pathogen, rotavirus: segmented genomes, nonequivalent packing of 120 subunits in its icosahedral capsid, and capsids as compartments for transcription and replication. ϕ6 assembles as a dodecahedral procapsid that undergoes major conformational changes as it matures into the spherical capsid. We determined the crystal structure of the capsid protein, P1, revealing a flattened trapezoid subunit with an α-helical fold. We also solved the procapsid with cryo-electron microscopy to comparable resolution. Fitting the crystal structure into the procapsid disclosed substantial conformational differences between the two P1 conformers. Maturation via two intermediate states involves remodeling on a similar scale, besides huge rigid-body rotations. The capsid structure and its stepwise maturation that is coupled to sequential packaging of three RNA segments sets the cystoviruses apart from other dsRNA viruses as a dynamic molecular machine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.