ArticleMedical hypotheses2013
Is anxious-depression an inflammatory state?
Article in Medical hypotheses, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04701801 (Correlation of Preoperative Anxiety With Early Postoperative Cognitive Dysfunction in Breast Cancer Patients), which is not on this map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Correlation of Preoperative Anxiety With Early Postoperative Cognitive Dysfunction in Breast Cancer Patients
Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
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- Association of Depression with Metabolic Syndrome in Highly Educated Ethnic Koreans of China: A Case-Control Study.Neuropsychiatric disease and treatment · 2021Article
- The association of preoperative anxiety and depression with neurocognitive disorder following oncological surgery.Journal of surgical oncology · 2020Observational
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- Anxiety Associated Increased CpG Methylation in the Promoter of Asb1: A Translational Approach Evidenced by Epidemiological and Clinical Studies and a Murine Model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- The role of anxious distress in immune dysregulation in patients with major depressive disorder.Translational psychiatry · 2017Article
- Cortical thickness and subcortical structure volume abnormalities in patients with major depression with and without anxious symptoms.Brain and behavior · 2017Article
- Peripheral inflammatory cytokines and immune balance in Generalised Anxiety Disorder: Case-controlled study.Brain, behavior, and immunity · 2017Article
- Psychometric Properties of the DASS-21 Among Latina/o College Students by the US-Mexico Border.Journal of immigrant and minority health · 2016Article
- Depressive symptoms are associated with tumor necrosis factor alpha in systemic lupus erythematosus.Journal of neuroinflammation · 2016Article
- Association of subsyndromal and depressive symptoms with inflammatory markers among different ethnic groups: the multi-ethnic study of atherosclerosis (MESA).Journal of affective disorders · 2014Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
For several years, the literature has examined the association of depression and anxiety with inflammatory states such as atherosclerosis and cardiovascular disease, yet this association remains inconclusive. Several possible immune and endocrinological pathways have been postulated that associate depression and anxiety with inflammation and immune dysregulation. Anxiety and depression have usually been envisioned as two separate psychiatric conditions yet they share similar symptoms and are frequently encountered together among individuals. Individuals suffering from anxious-depression are more refractory to treatment and have been reported to have greater disability compared to individuals with anxiety or depression alone. With the current changes in the diagnostic manual for psychiatric disorders placing more emphasis on a dimensional approach for the diagnosis of psychiatric illnesses, the hypothesis presented is that anxious-depression should be considered as a chronic inflammatory phenomenon since it shares common physiopathological pathways and pharmacological treatments with inflammatory states. This hypothesis might help to investigate how different levels of inflammatory biomarkers could be correlated with symptoms of anxious-depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.