Evidence map›Paper›PMID 23890997›Full record

ReviewLancet (London, England)2014

Type 1 diabetes.

Mark A Atkinson, George S Eisenbarth, Aaron W Michels

Registry-linked trialAbstract readReview
In one paragraph

Review in Lancet (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04545151 (A Randomised, Double-blind, Placebo Controlled, Parallel Group, Multi-centre Trial in Adult Subjects With Newly Diagnosed Type 1 Diabetes Mellitus Investigating the Effect of Verapamil SR on Preservation of Beta-cell Function), which is not on this map. Cited by 1,221 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,221citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04545151 phase2completednot on this mapstarted 2021, after this paper: background citation

A Randomised, Double-blind, Placebo Controlled, Parallel Group, Multi-centre Trial in Adult Subjects With Newly Diagnosed Type 1 Diabetes Mellitus Investigating the Effect of Verapamil SR on Preservation of Beta-cell Function (Ver-A-T1D)

TypeinterventionalSponsorMedical University of GrazRan2021 to 2026Enrolled136ConditionsDiabetes Mellitus, Type 1ArmsVerapamil SR 120 mg, Placebo
3 · Its place in the literature

Who cites it

1,221 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  13. Thalamic Nuclei Atrophy in Type 1 Diabetes Mellitus Across Disease Duration.Journal of magnetic resonance imaging : JMRI · 2026
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  14. Review
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1,161 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mark A AtkinsonDepartment of Pathology and Department of Pediatrics, University of Florida, Gainesville, FL, USA. Electronic address: atkinson@ufl.edu.
George S EisenbarthBarbara Davis Center for Childhood Diabetes, Aurora, CO, USA.
Aaron W MichelsBarbara Davis Center for Childhood Diabetes, Aurora, CO, USA.

Funding

Small Molecules Targeting Allele Specific MHC Class II PresentationK08DK095995 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI MICHELS, AARON W · 2012 to 2016
$762k
NIDDK NIH HHS K08 DK095995
6 · The paper itself

Abstract

Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes has grown substantially, particularly with regard to disease prediction and heterogeneity, pancreatic pathology, and epidemiology. Technological improvements in insulin pumps and continuous glucose monitors help patients with type 1 diabetes manage the challenge of lifelong insulin administration. Agents that show promise for averting debilitating disease-associated complications have also been identified. However, despite broad organisational, intellectual, and fiscal investments, no means for preventing or curing type 1 diabetes exists, and, globally, the quality of diabetes management remains uneven. This Seminar discusses current progress in epidemiology, pathology, diagnosis, and treatment of type 1 diabetes, and prospects for an improved future for individuals with this disease.

Indexed as

Diabetes Mellitus, Type 1HumansHypoglycemic AgentsInsulinIslets of LangerhansPancreas, ArtificialHypoglycemic AgentsInsulin

Identifiers

PMID23890997
PMCPMC4380133

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.