SynthesisArthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association2013
The basic science of continuous passive motion in promoting knee health: a systematic review of studies in a rabbit model.
Synthesis in Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Efficacy and safety of continuous passive motion and physical therapy in recovery from knee arthroplasty: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2024Pooled it
- Return-to-Play and Rehabilitation Protocols following Cartilage Restoration Procedures of the Knee: A Systematic Review.Cartilage · 2021Pooled it
- The Efficacy of Manual Therapy in Patients with Knee Osteoarthritis: A Systematic Review.Medicina (Kaunas, Lithuania) · 2021Pooled it
- Prolonged Application of Continuous Passive Movement Improves the Postoperative Recovery of Tibial Head Fractures: A Prospective Randomized Controlled Study.BioMed research international · 2022Trial
- [Research progress of Pendulum Leg Swing Therapy in treatment of knee osteoarthritis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
- Role of external forces in the mechanobiology of stem and differentiated chondrogenic cells embedded in a tissue-engineered construct for cartilage repair.Journal of biomedical science · 2026Review
- Continuous Passive Motion in the Rehabilitation of a Comminuted Patellar Fracture Following Delayed Physiotherapy Initiation: A Case Report.Clinical case reports · 2026Article
- Rehabilitation of the Knee After Autologous Matrix-Induced Chondrogenesis: A Systematic Review of Rehabilitation Protocols and Clinical and Radiological Outcomes.Orthopaedic journal of sports medicine · 2025Review
- Effectiveness of home based continuous passive motion compared with conventional physical therapy after arthroscopic release of degenerative elbow stiffness.Scientific reports · 2025Article
- A perspective on arthroscopic treatment for anterior ankle impingement syndrome: clinical research insights.Frontiers in surgery · 2025Review
- Mechanical stimulation promotes fibrochondrocyte proliferation by activating the TRPV4 signaling pathway during tendon-bone insertion healing: CCN2 plays an important regulatory role.Burns & trauma · 2024Article
- Hot spots and frontiers in bone-tendon interface research: a bibliometric analysis and visualization from 2000 to 2023.Frontiers in surgery · 2023Review
- Effect of hip CPM on gross motor function and development of the hip joint: a single-center randomized controlled study on spastic cerebral palsy children with hip dysplasia.Frontiers in pediatrics · 2023Article
- Physiotherapeutic Strategies and Their Current Evidence for Canine Osteoarthritis.Veterinary sciences · 2022Review
- The Most Common Rehabilitation Protocol After Matrix-Assisted Autologous Chondrocyte Implantation Is Immediate Partial Weight-Bearing and Continuous Passive Motion.Arthroscopy, sports medicine, and rehabilitation · 2022Review
- Complication of lengthening and the role of post-operative care, physical and psychological rehabilitation among fibula hemimelia.World journal of clinical cases · 2022Review
- Osteochondral Allografts in Knee Surgery: Narrative Review of Evidence to Date.Orthopedic research and reviews · 2022Review
- Rehabilitation and Return-to-Play Criteria After Fresh Osteochondral Allograft Transplantation: A Systematic Review.Orthopaedic journal of sports medicine · 2021Review
- Impact of Jiggling Exercise as Conservative Treatment for Hip Osteoarthritis: A Report of Two Cases.Case reports in orthopedics · 2020Article
- [Research progress of rehabilitation after autologous chondrocyte implantation on knee].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo determine whether the basic science evidence supports the use of continuous passive motion (CPM) after articular cartilage injury in the knee.
methodsA systematic review was performed identifying and evaluating studies in animal models that focused on the basic science of CPM of the knee. Databases included in this review were PubMed, Biosis Previews, SPORTDiscus, PEDro, and EMBASE. All functional, gross anatomic, histologic, and histochemical outcomes were extracted and analyzed.
resultsPrimary outcomes of CPM analyzed in rabbit animal models (19 studies) included histologic changes in articular cartilage (13 studies), biomechanical changes and nutrition of intra-articular tissue (3 studies), and anti-inflammatory biochemical changes (3 studies). Nine studies specifically examined osteochondral defects, 6 of which used autogenous periosteal grafts. Other pathologies included were antigen-induced arthritis, septic arthritis, medial collateral ligament reconstruction, hemarthrosis, and chymopapain-induced proteoglycan destruction. In comparison to immobilized knees, CPM therapy led to decreased joint stiffness and complications related to adhesions while promoting improved neochondrogenesis with formation and preservation of normal articular cartilage. CPM was also shown to create a strong anti-inflammatory environment by effectively clearing harmful, inflammatory particles from within the knee.
conclusionsCurrent basic science evidence from rabbit studies has shown that CPM for the knee significantly improves motion and biological properties of articular cartilage. This may be translated to potentially improved outcomes in the management of articular cartilage pathology of the knee. CLINICAL RELEVANCE: If the rabbit model is relevant to humans, CPM may contribute to improved knee health by preventing joint stiffness, preserving normal articular tissue with better histologic and biologic properties, and improving range of motion as compared with joint immobilization and intermittent active motion.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.