ArticleCritical care (London, England)2013
Re-evaluating currently available data and suggestions for planning randomised controlled studies regarding the use of hydroxyethyl starch in critically ill patients - a multidisciplinary statement.
Article in Critical care (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 90 citations in OpenAlex.
- Long-term outcomes in patients with severe sepsis randomised to resuscitation with hydroxyethyl starch 130/0.42 or Ringer's acetate.Intensive care medicine · 2014Trial
- Liberal or restricted fluid administration: are we ready for a proposal of a restricted intraoperative approach?BMC anesthesiology · 2014Trial
- Effects of hydroxyethyl starch in subgroups of patients with severe sepsis: exploratory post-hoc analyses of a randomised trial.Intensive care medicine · 2013Trial
- Article
- A Prospective Observational Study of Rational Fluid Therapy in Asian Intensive Care Units: Another Puzzle Piece in Fluid Therapy.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020Article
- Fluid resuscitation after severe trauma injury : U-shaped associations between tetrastarch dose and survival time or frequency of acute kidney failure.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2020Observational
- Understanding the Harms of HES: A Review of the Evidence to Date.Turkish journal of anaesthesiology and reanimation · 2019Review
- State of the art in fluid and volume therapy : A user-friendly staged concept. English version.Der Anaesthesist · 2019Article
- Is the literature inconclusive about the harm of HES? We are not sure.Intensive care medicine · 2017Article
- Intraoperative hydroxyethyl starch 70/0.5 administration may increase postoperative bleeding: a retrospective cohort study.Journal of anesthesia · 2017Article
- On the right side of the heart: Medical and mechanical support of the failing right ventricle.Journal of the Intensive Care Society · 2017Review
- [State of the art in fluid and volume therapy : A user-friendly staged concept].Der Anaesthesist · 2017Review
- Effect of goal-directed therapy on outcome after esophageal surgery: A quality improvement study.PloS one · 2017Observational
- Clinical practice in perioperative monitoring in adult cardiac surgery: is there a standard of care? Results from an national survey.Journal of clinical monitoring and computing · 2016Article
- Fluid Management for Critically Ill Patients: A Review of the Current State of Fluid Therapy in the Intensive Care Unit.Kidney diseases (Basel, Switzerland) · 2016Review
- Effects of different types of fluid resuscitation for hemorrhagic shock on splanchnic organ microcirculation and renal reactive oxygen species formation.Critical care (London, England) · 2015Article
- Reporting bias in trials of volume resuscitation with hydroxyethyl starch.Wiener klinische Wochenschrift · 2014Review
- Controversies in fluid therapy: Type, dose and toxicity.World journal of critical care medicine · 2014Review
- Existing trial data do not support that hydroxyethyl starch is less harmful when given on more 'correct' indications.Critical care (London, England) · 2013Article
- Use of hydroxyethyl starch in critically ill patients.Critical care (London, England) · 2013Article
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Authors and funding
19 authors at 14 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHydroxyethyl starch (HES) is a commonly used colloid in critically ill patients. However, its safety has been questioned in recent studies and meta-analyses.
methodsWe re-evaluated prospective randomised controlled trials (RCT) from four meta-analyses published in 2013 that compared the effect of HES with crystalloids in critically ill patients, focusing on the adherence to 'presumably correct indication'. Regarding the definition of 'presumably correct indication', studies were checked for the following six criteria (maximum six points): short time interval from shock to randomisation (<6 h), restricted use for initial volume resuscitation, use of any consistent algorithm for haemodynamic stabilisation, reproducible indicators of hypovolaemia, maximum dose of HES, and exclusion of patients with pre-existing renal failure or renal replacement therapy.
resultsDuration of fluid administration ranged from 90 min up to a maximum of 90 days. Four studies considered follow-up until 90-day mortality, three studies 28-/30-day mortality, whereas four studies reported only early mortality. Included studies showed a large heterogeneity of the indication score ranging between 1 and 4 points with a median (25%; 75% quartile) of 4 (2; 4).
conclusionsThe most important question, whether or not HES may be harmful when it is limited to immediate haemodynamic stabilisation, cannot be answered yet in the absence of any study sufficiently addressing this question. In order to overcome the limitations of most of the previous studies, we now suggest an algorithm emphasising the strict indication of HES. Additionally, we give a list of suggestions that should be adequately considered in any prospective RCT in the field of acute volume resuscitation in critically ill patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.