ArticleBMC microbiology2013
Sequence polymorphisms of rfbT among the Vibrio cholerae O1 strains in the Ogawa and Inaba serotype shifts.
Article in BMC microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- The spatio-temporal patterns and formation mechanisms of cholera epidemics in Hubei Province, China from 1949 to 2020.PLoS neglected tropical diseases · 2026Article
- Recent and convergent reversion to serotype Ogawa in the AFR12 sublineage ofMicrobial genomics · 2025Article
- Emergence and Prevalence of Vibrio cholerae O1 Sequence Type 75 Clonal Complex, Fujian Province, China, 2009-2023.Emerging infectious diseases · 2025Article
- Allelic variations and gene cluster modularity act as nonlinear bottlenecks for cholera emergence.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Emergence and genomic insights of non-pandemic O1Microbiology spectrum · 2023Article
- Molecular Basis of the Toxigenic Vibrio cholerae O1 Serotype Switch from Ogawa to Inaba in Haiti.Microbiology spectrum · 2023Article
- Serotype conversion geneFrontiers in microbiology · 2023Article
- Assessment and Antibiotic Resistance Profiling inAntibiotics (Basel, Switzerland) · 2021Article
- Dissecting serotype-specific contributions to live oral cholera vaccine efficacy.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Pandemic Vibrio cholerae shuts down site-specific recombination to retain an interbacterial defence mechanism.Nature communications · 2020Article
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- Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process.PLoS neglected tropical diseases · 2016Article
- Article
- The Resistance of Vibrio cholerae O1 El Tor Strains to the Typing Phage 919TP, a Member of K139 Phage Family.Frontiers in microbiology · 2016Article
- The role of China in the global spread of the current cholera pandemic.PLoS genetics · 2015Article
- Development of stable Vibrio cholerae O1 Hikojima type vaccine strains co-expressing the Inaba and Ogawa lipopolysaccharide antigens.PloS one · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVibrio cholerae serogroup O1 has two major serotypes, Ogawa and Inaba, which may alternate among cholera epidemics. The rfbT gene is responsible for the conversion between the two serotypes. In this study, we surveyed the sequence variance of rfbT in the Ogawa and Inaba strains in China over a 48-year (1961-2008) period in which serotype shifts occurred among epidemic years.
resultsVarious mutation events including single nucleotide, short fragment insertions/deletions and transposases insertions, were found in the rfbT gene of the Inaba strains. Ectopically introducing an intact rfbT could overcome the mutations by converting the Inaba serotype to the Ogawa serotype, suggesting the effects of these mutations on the function of RfbT. Characteristic rfbT mutations were recognized in the Inaba strains among Inaba serotype dominant epidemic years which were separate from the Ogawa dominant epidemics. Three distinguishable mutation sites in rfbT between the classical and the El Tor biotype strains were identified and could serve as biotype-specific biomarkers.
conclusionsOur results provide a comprehensive picture of the rfbT gene mutations among the V. cholerae O1 strains in different epidemic periods, which could be further used as the tracing markers in clonality analysis and dissemination surveillance of the epidemic strains.
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