ReviewJournal of clinical hypertension (Greenwich, Conn.)2013
The relationship between blood pressure and pain.
Review in Journal of clinical hypertension (Greenwich, Conn.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
128 citing papers in PubMed, 4 syntheses or guidelines pooled it, 283 citations in OpenAlex.
- Prevalence and Risk Factors of Diabetes in People with Low Back Pain: a Systematic Review and Meta-Analysis.Biochemical genetics · 2026Pooled it
- Are adults with chronic pain more likely to develop hypertension than adults without chronic pain? A systematic review and meta-analysis.British journal of anaesthesia · 2025Pooled it
- Effects of foot reflexology massage on pregnant women: a systematic review and meta-analysis of randomized controlled studies.Scientific reports · 2024Pooled it
- Prevalence of Poor Sleep Quality in Patients With Hypertension in China: A Meta-analysis of Comparative Studies and Epidemiological Surveys.Frontiers in psychiatry · 2020Pooled it
- Paramedic analgesia comparing ketamine and morphine in trauma. A synopsis of the PACKMaN double-blind RCT.Health technology assessment (Winchester, England) · 2026Trial
- Premixed nitrous oxide/oxygen analgesia for removal of vacuum assisted closure dressing: a randomized, double-blinded placebo-controlled trial.Scientific reports · 2026Trial
- Evaluation of the Anaesthetic Efficacies of Three Different Formulations of Intraligamentary Injections for Hypertensive Patients with Symptomatic Irreversible Pulpitis: A Randomised Controlled Trial.European endodontic journal · 2025Trial
- Acute self-myofascial release modulates cardiac autonomic function and hemodynamic parameters at rest and reduces cardiovascular stress reaction.European journal of applied physiology · 2024Trial
- Effect of epidural dexmedetomidine in single-dose combined with ropivacaine for cesarean section.BMC anesthesiology · 2024Trial
- A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers.Journal of psychopharmacology (Oxford, England) · 2021Trial
- The incidence of persistent postoperative opioid use among U.S. veterans: A national study to identify risk factors.Journal of clinical anesthesia · 2021Trial
- Intra-operative effect of interscalene brachial plexus block to arthroscopic rotator cuff repair surgery.International orthopaedics · 2019Trial
- The Efficacy of Fixed-Dose Diclofenac and Orphenadrine for Postoperative Pain Management: A Systematic Review.Medicines (Basel, Switzerland) · 2026Review
- Celiac trunk thrombosis and splenic infarction in a patient with ankylosing spondylitis under adalimumab: a case report.International journal of emergency medicine · 2026Article
- Novel objective-subjective pain assessment score results in decreased opioid prescription after elective spine surgery: a prospective pilot study.Acta neurochirurgica · 2026Article
- Associations of Arterial Blood Pressure With Radiographic Knee Osteoarthritis and Pain Sensitivity in Middle-Aged and Older Adults.European journal of pain (London, England) · 2026Article
- Acute pain and analgesic prescribing in trauma inpatients at a tertiary hospital: A cross-sectional study.Journal of the colleges of medicine of South Africa · 2026Article
- Hypertension is associated with knee osteoarthritis pain in an age-dependent manner.Experimental gerontology · 2025Article
- Pain and blood pressure: short-term physiological benefit, long-term pathological harm?British journal of anaesthesia · 2025Article
- Prevalence and Risk Factors of Musculoskeletal Pain Among Kuwaiti Pilgrims During Hajj 2024.International journal of environmental research and public health · 2025Article
68 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between pain and hypertension is potentially of great pathophysiological and clinical interest, but is poorly understood. The perception of acute pain initially plays an adaptive role, which results in the prevention of tissue damage. The consequence of ascending nociception is the recruitment of segmental spinal reflexes through the physiological neuronal connections. In proportion to the magnitude and duration of the stimulus, these spinal reflexes cause the activation of the sympathetic nervous system, which increases peripheral resistances, heart rate, and stroke volume. The response also involves the neuroendocrine system, and, in particular, the hypothalamic-pituitary-adrenal axis, in addition to further activation of the sympathetic system by adrenal glands. However, in proportion to an elevation in resting blood pressure, there is a contemporary and progressive reduction in sensitivity to acute pain, which could result in a tendency to restore arousal levels in the presence of painful stimuli. The pathophysiological pattern is significantly different in the setting of chronic pain, in which the adaptive relationship between blood pressure and pain sensitivity is substantially reversed. The connection between acute or chronic pain and cardiovascular changes is supported observationally, but some of this indirect evidence is confirmed by experimental models and human studies. The pain regulatory process and functional interaction between cardiovascular and pain regulatory systems are briefly reviewed. Various data obtained are described, together with their potential clinical implications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.