ArticleAlcoholism, clinical and experimental research2013
Long-term modulation of A-type K(+) conductances in hippocampal CA1 interneurons in rats after chronic intermittent ethanol exposure during adolescence or adulthood.
Article in Alcoholism, clinical and experimental research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Age-related differences in the effect of chronic alcohol on cognition and the brain: a systematic review.Translational psychiatry · 2022Pooled it
- Adolescent intermittent ethanol exposure alters adult exploratory and affective behaviors, and cerebellar Grin2b expression in C57BL/6J mice.Drug and alcohol dependence · 2023Article
- Cognitive Alterations in Addictive Disorders: A Translational Approach.Biomedicines · 2023Review
- The role of sex in the persistent effects of adolescent alcohol exposure on behavior and neurobiology in rodents.International review of neurobiology · 2021Review
- Chronic mild stress alters synaptic plasticity in the nucleus accumbens through GSK3β-dependent modulation of Kv4.2 channels.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Mechanisms of Persistent Neurobiological Changes Following Adolescent Alcohol Exposure: NADIA Consortium Findings.Alcoholism, clinical and experimental research · 2019Review
- GSK3β Modulates Timing-Dependent Long-Term Depression Through Direct Phosphorylation of Kv4.2 Channels.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Effect of Alcohol on Hippocampal-Dependent Plasticity and Behavior: Role of Glutamatergic Synaptic Transmission.Frontiers in behavioral neuroscience · 2019Review
- Donepezil Reverses Dendritic Spine Morphology Adaptations and Fmr1 Epigenetic Modifications in Hippocampus of Adult Rats After Adolescent Alcohol Exposure.Alcoholism, clinical and experimental research · 2018Article
- The reinforcing properties of ethanol are quantitatively enhanced in adulthood by peri-adolescent ethanol, but not saccharin, consumption in female alcohol-preferring (P) rats.Alcohol (Fayetteville, N.Y.) · 2015Article
- Adolescent intermittent alcohol exposure: persistence of structural and functional hippocampal abnormalities into adulthood.Alcoholism, clinical and experimental research · 2015Article
- Neuroimmune Function and the Consequences of Alcohol Exposure.Alcohol research : current reviews · 2015Review
- Adolescent alcohol exposure alters GABAA receptor subunit expression in adult hippocampus.Alcoholism, clinical and experimental research · 2014Article
- Adolescent alcohol exposure and persistence of adolescent-typical phenotypes into adulthood: a mini-review.Neuroscience and biobehavioral reviews · 2014Review
- Neurochemical mechanisms of alcohol withdrawal.Handbook of clinical neurology · 2014Review
- Neuroimmune basis of alcoholic brain damage.International review of neurobiology · 2014Review
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundChronic alcohol use, especially exposure to alcohol during adolescence or young adulthood, is closely associated with cognitive deficits that may persist into adulthood. Therefore, it is essential to identify possible neuronal mechanisms underlying the observed deficits in learning and memory. Hippocampal interneurons play a pivotal role in regulating hippocampus-dependent learning and memory by exerting strong inhibition on excitatory pyramidal cells. The function of these interneurons is regulated not only by synaptic inputs from other types of neurons but is also precisely governed by their own intrinsic membrane ionic conductances. The voltage-gated A-type potassium current (IA ) regulates the intrinsic membrane properties of neurons, and disruption of IA is responsible for many neuropathological processes including learning and memory deficits. Thus, it represents a previously unexplored cellular mechanism whereby chronic ethanol (EtOH) may alter hippocampal memory-related functioning.
methodsUsing whole-cell electrophysiological recording methods, we investigated the enduring effects of chronic intermittent ethanol (CIE) exposure during adolescence or adulthood on IA in rat CA1 interneurons.
resultsWe found that the mean peak amplitude of IA was significantly reduced after CIE in either adolescence or adulthood, but IA density was attenuated after CIE in adolescence but not after CIE in adulthood. In addition, the voltage-dependent steady-state activation and inactivation of IA were altered in interneurons after CIE.
conclusionsThese findings suggest that CIE can cause long-term changes in IA channels in interneurons and thus may alter their inhibitory influences on memory-related local hippocampal circuits, which could be, in turn, responsible for learning and memory impairments observed after chronic EtOH exposure.
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