ArticleScandinavian journal of medicine & science in sports2013
Increased mast cell numbers in a calcaneal tendon overuse model.
Article in Scandinavian journal of medicine & science in sports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 54 citations in OpenAlex.
- Tendinopathy: The Interplay between Mechanical Stress, Inflammation, and Vascularity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Sixteen weeks of high-speed treadmill running is insufficient to induce Achilles tendinopathy in a rat model.American journal of physiology. Cell physiology · 2025Article
- Single-cell RNA sequencing reveals the CRTAC1Aging cell · 2024Article
- Challenges in tendon-bone healing: emphasizing inflammatory modulation mechanisms and treatment.Frontiers in endocrinology · 2024Review
- LeveragingFrontiers in bioengineering and biotechnology · 2024Review
- Mast Cell Involvement in the Pathogenesis of Selected Musculoskeletal Diseases.Life (Basel, Switzerland) · 2023Review
- Optogenetic-induced muscle loading leads to mechanical adaptation of the Achilles tendon enthesis in mice.Science advances · 2023Article
- Optogenetic-Induced Muscle Loading Leads to Mechanical Adaptation of the Achilles Tendon Enthesis in Mice.bioRxiv : the preprint server for biology · 2023Article
- The Effects of Downhill Running and Maturation on Histological and Morphological Properties of Tendon and Enthesis in Mice.Biology · 2023Article
- The roles and therapeutic potentialof mesenchymal stem/stromal cells and their extracellular vesicles in tendinopathies.Frontiers in bioengineering and biotechnology · 2023Review
- Innate and adaptive immune system cells implicated in tendon healing and disease.European cells & materials · 2022Review
- Tendon healing is adversely affected by low-grade inflammation.Journal of orthopaedic surgery and research · 2021Review
- Tendinopathy and tendon material response to load: What we can learn from small animal studies.Acta biomaterialia · 2021Review
- Local shifts in inflammatory and resolving lipid mediators in response to tendon overuse.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Bringing tendon biology to heel: Leveraging mechanisms of tendon development, healing, and regeneration to advance therapeutic strategies.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Review
- Molecular and Structural Effects of Percutaneous Interventions in Chronic Achilles Tendinopathy.International journal of molecular sciences · 2020Review
- Using tools in mechanobiology to repair tendons.Current tissue microenvironment reports · 2020Article
- Review
- The shift in macrophages polarisation after tendon injury: A systematic review.Journal of orthopaedic translation · 2020Review
- Recent advances in tendinopathy.Faculty reviews · 2020Review
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tendinopathy is often discovered late because the initial development of tendon pathology is asymptomatic. The aim of this study was to examine the potential role of mast cell involvement in early tendinopathy using a high-intensity uphill running (HIUR) exercise model. Twenty-four male Wistar rats were divided in two groups: running group (n = 12); sedentary control group (n = 12). The running-group was exposed to the HIUR exercise protocol for 7 weeks. The calcaneal tendons of both hind limbs were dissected. The right tendon was used for histologic analysis using Bonar score, immunohistochemistry, and second harmonic generation microscopy (SHGM). The left tendon was used for quantitative polymerase chain reaction (qPCR) analysis. An increased tendon cell density in the runners were observed compared to the controls (P = 0.05). Further, the intensity of immunostaining of protein kinase B, P = 0.03; 2.75 ± 0.54 vs 1.17 ± 0.53, was increased in the runners. The Bonar score (P = 0.05), and the number of mast cells (P = 0.02) were significantly higher in the runners compared to the controls. Furthermore, SHGM showed focal collagen disorganization in the runners, and reduced collagen density (P = 0.03). IL-3 mRNA levels were correlated with mast cell number in sedentary animals. The qPCR analysis showed no significant differences between the groups in the other analyzed targets. The current study demonstrates that 7-week HIUR causes structural changes in the calcaneal tendon, and further that these changes are associated with an increased mast cell density.
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Registered trials
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