ArticleJournal of materials science. Materials in medicine2013
Carbonic anhydrase immobilized on hollow fiber membranes using glutaraldehyde activated chitosan for artificial lung applications.
Article in Journal of materials science. Materials in medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Recent Advances and Future Directions in Extracorporeal Carbon Dioxide Removal.Journal of clinical medicine · 2024Review
- Nanotopography-enhanced biomimetic coating maintains bioactivity after weeks of dry storage and improves chronic neural recording.Biomaterials · 2023Article
- Direct Biocatalytic Processes for COMolecules (Basel, Switzerland) · 2023Review
- Developing Enzyme Immobilization with Fibrous Membranes: Longevity and Characterization Considerations.Membranes · 2023Review
- Biocatalytic Membranes for Carbon Capture and Utilization.Membranes · 2023Review
- Physiological Basis of Extracorporeal Membrane Oxygenation and Extracorporeal Carbon Dioxide Removal in Respiratory Failure.Membranes · 2021Review
- Toward a Long-Term Artificial Lung.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2020Review
- Carbonic anhydrase modification for carbon management.Environmental science and pollution research international · 2020Article
- [Current techniques for extracorporeal decarboxylation].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2019Review
- Development of zwitterionic sulfobetaine block copolymer conjugation strategies for reduced platelet deposition in respiratory assist devices.Journal of biomedical materials research. Part B, Applied biomaterials · 2018Article
- Enhancing surface immobilization of bioactive moleculesJournal of materials chemistry. B · 2018Article
- Extracorporeal COIntensive care medicine experimental · 2017Article
- Extracorporeal carbon dioxide removal (ECCOJournal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2017Review
- Acidic sweep gas with carbonic anhydrase coated hollow fiber membranes synergistically accelerates CO2 removal from blood.Acta biomaterialia · 2015Article
- Kinetics of CO2 exchange with carbonic anhydrase immobilized on fiber membranes in artificial lungs.Journal of materials science. Materials in medicine · 2015Article
- Hollow fiber membrane modification with functional zwitterionic macromolecules for improved thromboresistance in artificial lungs.Langmuir : the ACS journal of surfaces and colloids · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Extracorporeal CO2 removal from circulating blood is a promising therapeutic modality for the treatment of acute respiratory failure. The enzyme carbonic anhydrase accelerates CO2 removal within gas exchange devices by locally catalyzing HCO3 (-) into gaseous CO2 within the blood. In this work, we covalently immobilized carbonic anhydrase on the surface of polypropylene hollow fiber membranes using glutaraldehyde activated chitosan tethering to amplify the density of reactive amine functional groups for enzyme immobilization. XPS and a colorimetric amine assay confirmed higher amine densities on the chitosan coated fiber compared to control fiber. Chitosan/CA coated fibers exhibited accelerated CO2 removal in scaled-down gas exchange devices in buffer and blood (115% enhancement vs. control, 37% enhancement vs. control, respectively). Carbonic anhydrase immobilized directly on hollow fiber membranes without chitosan tethering resulted in no enhancement in CO2 removal. Additionally, fibers coated with chitosan/carbonic anhydrase demonstrated reduced platelet adhesion when exposed to blood compared to control and heparin coated fibers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.