ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
Curcumin inhibits lung cancer progression and metastasis through induction of FOXO1.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Analysis of Promoter Methylation of the BovineAnimals : an open access journal from MDPI · 2023Article
- Integrative Approaches to the Treatment of Cancer.Cancers · 2022Review
- Apoptosis of mouse myeloma cells induced by curcumin via the Notch3-p53 signaling axis.Oncology letters · 2019Article
- Role of Forkhead Box Class O proteins in cancer progression and metastasis.Seminars in cancer biology · 2018Review
- MicroRNA-122-3p inhibits tumor cell proliferation and induces apoptosis by targeting Forkhead box O in A549 cells.Oncology letters · 2018Article
- Daurinol blocks breast and lung cancer metastasis and development by inhibition of focal adhesion kinase (FAK).Oncotarget · 2017Article
- Antitumor effects of curcumin in human bladder cancerOncology letters · 2017Article
- Inhibition of microRNA-181a may suppress proliferation and invasion and promote apoptosis of cervical cancer cells through the PTEN/Akt/FOXO1 pathway.Journal of physiology and biochemistry · 2016Article
- Plant Polyphenols as Chemopreventive Agents for Lung Cancer.International journal of molecular sciences · 2016Review
- Cancer prevention and therapy through the modulation of the tumor microenvironment.Seminars in cancer biology · 2015Review
- Potential anti-cancer effect of curcumin in human lung squamous cell carcinoma.Thoracic cancer · 2015Article
- The multifaceted role of curcumin in cancer prevention and treatment.Molecules (Basel, Switzerland) · 2015Review
- MiR-135b promotes proliferation and invasion of osteosarcoma cells via targeting FOXO1.Molecular and cellular biochemistry · 2015Article
- MiR-374a promotes the proliferation of human osteosarcoma by downregulating FOXO1 expression.International journal of clinical and experimental medicine · 2015Article
- Curcumin inhibits lung cancer invasion and metastasis by attenuating GLUT1/MT1-MMP/MMP2 pathway.International journal of clinical and experimental medicine · 2015Article
- Linking diet to acne metabolomics, inflammation, and comedogenesis: an update.Clinical, cosmetic and investigational dermatology · 2015Review
- Validating antimetastatic effects of natural products in an engineered microfluidic platform mimicking tumor microenvironment.Molecular pharmaceutics · 2014Article
- Curcumin Inhibits the Migration and Invasion of Non-Small-Cell Lung Cancer Cells Through Radiation-Induced Suppression of Epithelial-Mesenchymal Transition and Soluble E-Cadherin Expression.Technology in cancer research & treatmentArticle
Corrections and comments
- Retraction · 2017-04-20Compromised Peer Review · Investigation by Journal/Publisher · · Journal published by SAGE starting in 2017
- Retracted
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent population studies provide clues that the use of curcumin may be associated with reduced incidence and improved prognosis of certain cancers. In the present study, we demonstrated that curcumin acted as a growth inhibitor for lung cancer cells. Our results found that curcumin inhibited cell proliferation, which was associated with upregulation of the cyclin-dependent kinase inhibitors, p27 and p21, and downregulation of cyclin D1. In addition, we showed that curcumin induced the expression of forkhead box protein O1 (FOXO1) through activation of extracellular signal-regulated kinase 1/2 signaling. These findings provide evidence for a mechanism that may contribute to the antineoplastic effects of curcumin and justify further work to explore potential roles for activators of FOXO1 in the prevention and treatment of lung cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.