ArticleNucleic acids research1990
Characterization of the human spr2 promoter: induction after UV irradiation or TPA treatment and regulation during differentiation of cultured primary keratinocytes.
Article in Nucleic acids research, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 72 citations in OpenAlex.
- Regulation of antimicrobial peptide expression in human gingival keratinocytes by interleukin-1α.Archives of oral biology · 2011Article
- Detection of UV-induced activation of NF-kappaB in a recombinant human cell line by means of Enhanced Green Fluorescent Protein (EGFP).Radiation and environmental biophysics · 2007Article
- Re-expression of SPR1 in breast cancer cells by phorbol 12-myristate 13-acetate (PMA) or UV irradiation is mediated by the AP-1 binding site in the SPR1 promoter.Molecular medicine (Cambridge, Mass.) · 1999Article
- Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development.The American journal of pathology · 1997Article
- Regulation of keratinocyte proliferation and differentiation by all-trans-retinoic acid, 9-cis-retinoic acid and 1,25-dihydroxy vitamin D3.Archives of dermatological research · 1996Article
- Interdependent transcription control elements regulate the expression of the SPRR2A gene during keratinocyte terminal differentiation.Molecular and cellular biology · 1996Article
- Identification of two cDNA clones encoding small proline-rich proteins expressed in sheep ruminal epithelium.The Biochemical journal · 1996Article
- The 5' noncoding region of the mouse involucrin gene: comparison with the human gene and genes encoding other cornified envelope precursors.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
- Calcium inhibits epidermal growth factor-induced activation of p21ras in human primary keratinocytes.Molecular and cellular biology · 1994Article
- Cornifin, a cross-linked envelope precursor in keratinocytes that is down-regulated by retinoids.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1990Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have isolated genomic clones from several members of the UV and TPA inducible human spr2 gene-family in order to analyse the regulation of these genes at a molecular level. From one of these members, the spr2-1 gene, we have identified and sequenced the regulatory region. By using CAT fusion plasmids and a liposome mediated transfection procedure we show that the isolated promoter region contains all the cis-elements necessary for induced expression after UV irradiation or phorbolester treatment of cultured human keratinocytes. Additionally the spr2-1 promoter is shown to be regulated aswell during the normal process of keratinocyte differentiation. This makes the spr2-1 promoter sequence an ideal tool to study the molecular mechanisms by which environmental agents such as UV radiation and chemical tumor promoters interfere with normal gene expression during cell proliferation and differentiation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.