ArticleFrontiers in neural circuits2013
Synchronization through nonreciprocal connections in a hybrid hippocampus microcircuit.
Article in Frontiers in neural circuits, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Modeling the Effect of Temperature on Membrane Response of Light Stimulation in Optogenetically-Targeted Neurons.Frontiers in computational neuroscience · 2020Article
- Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor.Nature communications · 2018Article
- Chrna2-Martinotti Cells Synchronize Layer 5 Type A Pyramidal Cells via Rebound Excitation.PLoS biology · 2017Article
- Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca.Journal of neurophysiology · 2015Article
- Control of Phasic Firing by a Background Leak Current in Avian Forebrain Auditory Neurons.Frontiers in cellular neuroscience · 2015Article
- Automatic tracking of cells for video microscopy in patch clamp experiments.Biomedical engineering online · 2014Article
- Article
- Ih tunes theta/gamma oscillations and cross-frequency coupling in an in silico CA3 model.PloS one · 2013Article
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3 authors.
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Abstract
Synchronization among neurons is thought to arise from the interplay between excitation and inhibition; however, the connectivity rules that contribute to synchronization are still unknown. We studied these issues in hippocampal CA1 microcircuits using paired patch clamp recordings and real time computing. By virtually connecting a model interneuron with two pyramidal cells (PCs), we were able to test the importance of connectivity in synchronizing pyramidal cell activity. Our results show that a circuit with a nonreciprocal connection between pyramidal cells and no feedback from PCs to the virtual interneuron produced the greatest level of synchronization and mutual information between PC spiking activity. Moreover, we investigated the role of intrinsic membrane properties contributing to synchronization where the application of a specific ion channel blocker, ZD7288 dramatically impaired PC synchronization. Additionally, background synaptic activity, in particular arising from NMDA receptors, has a large impact on the synchrony observed in the aforementioned circuit. Our results give new insights to the basic connection paradigms of microcircuits that lead to coordination and the formation of assemblies.
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