ArticleThe Journal of infectious diseases2013
Plasma and cerebrospinal proteomes from children with cerebral malaria differ from those of children with other encephalopathies.
Article in The Journal of infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- An update on cerebral malaria for therapeutic intervention.Molecular biology reports · 2022Review
- The use of proteomics for the identification of promising vaccine and diagnostic biomarkers inParasitology · 2020Review
- Autoantibodies and Malaria: Where We Stand? Insights Into Pathogenesis and Protection.Frontiers in cellular and infection microbiology · 2020Review
- Quantitative proteomic analysis of cerebrospinal fluid from patients with diffuse large B-cell lymphoma with central nervous system involvement: A novel approach to diagnosis.Biomedical reports · 2019Article
- Anti-band 3 and anti-spectrin antibodies are increased in Plasmodium vivax infection and are associated with anemia.Scientific reports · 2018Article
- Quantitative Proteomics Analysis of Plasmodium vivax Induced Alterations in Human Serum during the Acute and Convalescent Phases of Infection.Scientific reports · 2017Article
- Cerebrospinal fluid markers to distinguish bacterial meningitis from cerebral malaria in children.Wellcome open research · 2017Article
- Clinicopathological Analysis and Multipronged Quantitative Proteomics Reveal Oxidative Stress and Cytoskeletal Proteins as Possible Markers for Severe Vivax Malaria.Scientific reports · 2016Article
- Use of a rapid test to assess plasma Plasmodium falciparum HRP2 and guide management of severe febrile illness.Malaria journal · 2015Article
- Quantification of Plasmodium falciparum histidine-rich protein-2 in cerebrospinal spinal fluid from cerebral malaria patients.The American journal of tropical medicine and hygiene · 2014Article
- Pathogenesis of cerebral malaria--inflammation and cytoadherence.Frontiers in cellular and infection microbiology · 2014Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Clinical signs and symptoms of cerebral malaria in children are nonspecific and are seen in other common encephalopathies in malaria-endemic areas. This makes accurate diagnosis difficult in resource-poor settings. Novel malaria-specific diagnostic and prognostic methods are needed. We have used 2 proteomic strategies to identify differentially expressed proteins in plasma and cerebrospinal fluid from children with a diagnosis of cerebral malaria, compared with those with a diagnosis of malaria-slide-negative acute bacterial meningitis and other nonspecific encephalopathies. Here we report the presence of differentially expressed proteins in cerebral malaria in both plasma and cerebrospinal fluid that could be used to better understand pathogenesis and help develop more-specific diagnostic methods. In particular, we report the expression of 2 spectrin proteins that have known Plasmodium falciparum-binding partners involved in the stability of the infected red blood cell, suppressing further invasion and possibly enhancing the red blood cell's ability to sequester in microvasculature.
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Registered trials
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