ReviewJournal of applied physiology (Bethesda, Md. : 1985)2014
Muscle blood flow, hypoxia, and hypoperfusion.
Review in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 84 citations in OpenAlex.
- Cardiorespiratory and oxygenation responses in iron-deficient anemic women during whole-body exercise under moderate hypoxia.European journal of applied physiology · 2026Trial
- β-Adrenergic receptors mediate sex differences in vasodilation but not sympathetic-mediated vasoconstriction during hypoxia.American journal of physiology. Heart and circulatory physiology · 2025Trial
- Five Days of Tart Cherry Supplementation Improves Exercise Performance in Normobaric Hypoxia.Nutrients · 2023Trial
- Prolonged adenosine triphosphate infusion and exercise hyperemia in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Trial
- Acute dietary nitrate supplementation enhances compensatory vasodilation during hypoxic exercise in older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Trial
- Citrate accumulation during regional citrate anticoagulation for continuous renal replacement therapy: a narrative review.Renal failure · 2026Review
- The pathophysiology of wild-type transthyretin amyloidosis: implications for exercise intolerance.American journal of physiology. Heart and circulatory physiology · 2026Review
- On the adaptive significance of group III/IV muscle afferent feedback for the cardiovascular response during sustained locomotion in humans.The Journal of physiology · 2026Article
- High-Intensity Exercise Performance as a Complex Adaptive System: An Integrative Review.Muscles (Basel, Switzerland) · 2026Review
- Sex-related differences in the peripheral vascular response to hypoxia: Implications in health and relevance for obstructive sleep apnoea.Experimental physiology · 2026Review
- The effect of sex on the isolated and combined α- and β-adrenergic control of blood flow during handgrip in adults at high altitude: An exploratory study.Physiological reports · 2026Article
- Effect of hypoxia-inducible factor 1 alpha inhibitor on immobilization-induced muscle fibrosis related to muscle contracture.Journal of physical therapy science · 2025Article
- The effects of needle and warm needle on hemodynamic responses at different acupoints in patients with knee osteoarthritis.Frontiers in bioengineering and biotechnology · 2025Article
- Gastrointestinal function and microbiota in endurance athletes.Frontiers in physiology · 2025Review
- Effects of endurance exercise under hypoxic conditions on the gastric emptying rate and intestinal cell damage.European journal of applied physiology · 2025Article
- Exercise-induced potentiation of the acute hypoxic ventilatory response: Neural mechanisms and implications for cerebral blood flow.Experimental physiology · 2024Review
- Electrical Stimulation-Based Twitch Exercise Suppresses Progression of Immobilization-Induced Muscle Fibrosis via Downregulation of PGC-1?/VEGF Pathway.Physiological research · 2024Article
- Assessment of ipsilateral and contralateral perfusion after contrast compression therapy of upper limb muscles in MMA athletes - a cross-over study.Frontiers in physiology · 2024Article
- Quadriceps fatigue during hypoxic and ischemic knee-extension exercise is similar in males and females.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Neuromuscular and Muscle Tissue Hemodynamic Responses When Exposed to Normobaric Hypoxia during Lower-Body Fatiguing Muscle Actions.Journal of musculoskeletal & neuronal interactions · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Blood flow increases to exercising skeletal muscle, and this increase is driven primarily by vasodilation in the contracting muscles. When oxygen delivery to the contracting muscles is altered by changes in arterial oxygen content, the magnitude of the vasodilator response to exercise changes. It is augmented during hypoxia and blunted during hyperoxia. Because the magnitude of the increased vasodilation during hypoxic exercise tends to keep oxygen delivery to the contracting muscles constant, we have termed this phenomenon "compensatory vasodilation." In a series of studies, we have explored metabolic, endothelial, and neural mechanisms that might contribute to compensatory vasodilation. These include the contribution of vasodilating substances like nitric oxide (NO) and adenosine, along with altered interactions between sympathetic vasoconstriction and metabolic vasodilation. We have also compared the compensatory vasodilator responses to hypoxic exercise with those seen when oxygen delivery to contracting muscles is altered by acute reductions in perfusion pressure. A synthesis of our findings indicate that NO contributes to the compensatory dilator responses during both hypoxia and hypoperfusion, while adenosine appears to contribute only during hypoperfusion. During hypoxia, the NO-mediated component is linked to a β-adrenergic receptor mechanism during lower intensity exercise, while another source of NO is engaged at higher exercise intensities. There are also subtle interactions between α-adrenergic vasoconstriction and metabolic vasodilation that influence the responses to hypoxia, hyperoxia, and hypoperfusion. Together our findings emphasize both the tight linkage of oxygen demand and supply during exercise and the redundant nature of the vasomotor responses to contraction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.