Evidence map›Paper›PMID 23887897›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2013

β-Adrenergic receptor antagonism in mice: a model for pediatric heart disease.

Carmen C Sucharov, Jamie G Hijmans, Rebecca D Sobus, William F A Melhado, Shelley D Miyamoto, Brian L Stauffer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Congenital Heart Disease: An Immunological Perspective.Frontiers in cardiovascular medicine · 2021
    Review
  8. Increased myocyte calcium sensitivity in end-stage pediatric dilated cardiomyopathy.American journal of physiology. Heart and circulatory physiology · 2019
    Article
  9. Article
  10. Review
  11. Acute isoproterenol leads to age-dependent arrhythmogenesis in guinea pigs.American journal of physiology. Heart and circulatory physiology · 2018
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Carmen C SucharovDepartment of Medicine, Division of Cardiology, University of Colorado School of Medicine, Aurora, Colorado;
Jamie G Hijmans
Rebecca D Sobus
William F A Melhado
Shelley D Miyamoto
Brian L Stauffer
University of Colorado Denver · USHospital Authority · CN

Funding

Molecular and Functional Mechanisms of Pediatric Heart FailureR01HL107715 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI STAUFFER, BRIAN L · 2012 to 2016
$2.8M
Mechanisms of YY1 Inhibition of Cardiac HypertrophyK01HL088708 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI SUCHAROV, CARMEN C · 2007 to 2011
$646k
Diet, Sex Steroids and CardiomyopathyK08HL080212 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI STAUFFER, BRIAN L · 2007 to 2011
$616k
Cardiac Beta-Adrenergic Adaptation in Pediatric Heart FailureR21HL097123 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MIYAMOTO, SHELLEY DEANNE, STAUFFER, BRIAN L · 2009 to 2010
$413k
NHLBI NIH HHS K01 HL-088708NHLBI NIH HHS K08 HL-080212NHLBI NIH HHS R01 HL-107715NHLBI NIH HHS R01 HL107715NHLBI NIH HHS R21 HL-097123
6 · The paper itself

Abstract

Children with heart failure are treated with similar medical therapy as adults with heart failure. In contrast to adults with heart failure, these treatment regiments are not associated with improved outcomes in children. Recent studies have demonstrated age-related pathophysiological differences in the molecular mechanisms of heart failure between children and adults. There are no animal models of pediatric cardiomyopathy to allow mechanistic studies. The purpose of the current experiments was to develop a mouse model of pediatric heart disease and test whether the influence of β-adrenergic receptor (β-AR) antagonism could be modeled in this system. We hypothesized that isoproterenol treatment of young mice would provide a model system of cardiac pathology, and that nonselective β-AR blockade would provide benefit in adult, but not young, mice, similar to clinical trial data. We found that isoproterenol treatment (through osmotic minipump implantation) of young and adult mice produced similar degrees of cardiac hypertrophy and recapitulated several age-related molecular abnormalities in human heart failure, including phospholamban phosphorylation and β-AR expression. We also found that nonselective β-AR blockade effectively prevented pathological cardiac growth and collagen expression in the adult but not young mice, and that selective β1-AR blockade was effective in both young and adult isoproterenol-treated mice. In conclusion, we have developed the first model system for β-AR-mediated pediatric heart disease. Furthermore, we have generated novel data suggesting beneficial effects of selective β1-AR blockade in the pediatric heart.

Indexed as

Adrenergic beta-1 Receptor AntagonistsAnimalsChildDisease Models, AnimalHeartHeart DiseasesHumansIsoproterenolMiceReceptors, Adrenergic, betaAdrenergic beta-1 Receptor AntagonistsIsoproterenolReceptors, Adrenergic, betaantagonistheart failurepediatricphospholambanβ-adrenergic receptor

Identifiers

PMID23887897
PMCPMC3798823
OpenAlexW1981080824

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.