Trial reportStroke2013
Cerebral atherosclerosis is associated with cystic infarcts and microinfarcts but not Alzheimer pathologic changes.
Trial report in Stroke, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Acupuncture for vascular mild cognitive impairment: an updated systematic review and meta-analysis of randomized controlled trials.Systematic reviews · 2026Pooled it
- Hypertension and Alzheimer's disease pathology at autopsy: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Pooled it
- Identifying patterns of neuropathological diagnoses in medico-legal autopsies - A latent class analysis of 1270 neuropathologically examined cases from Finland.Forensic science, medicine, and pathology · 2026Article
- Segmentation and morphometry of intracranial internal carotid artery calcification in relation to brain atrophy.Neuroradiology · 2026Article
- The Peripheral Amyloid-β Nexus: Connecting Alzheimer's Disease with Atherosclerosis through Shared Pathophysiological Mechanisms.Neuromolecular medicine · 2025Review
- The pathobiology of neurovascular aging.Neuron · 2025Review
- Hypertension may associate with cerebral small vessel disease and infarcts through the pathway of intracranial atherosclerosis.Neurobiology of aging · 2025Article
- Exploring the neuroprotective role of physical activity in cerebral small vessel disease.Brain research · 2024Review
- Histopathological Analysis of Cerebrovascular Lesions Associated With Aging.Journal of neuropathology and experimental neurology · 2022Observational
- Vascular pathology and pathogenesis of cognitive impairment and dementia in older adults.Cerebral circulation - cognition and behavior · 2022Article
- Alzheimer's Disease at a Crossroad: Time to Part from Amyloid to More Promising Aspects-Atherosclerosis for a Start.Journal of Alzheimer's disease : JAD · 2022Article
- Potential of Glucagon-Like Peptide 1 as a Regulator of Impaired Cholesterol Metabolism in the Brain.Advances in nutrition (Bethesda, Md.) · 2020Review
- Hypertension and Alzheimer's disease: indirect effects through circle of Willis atherosclerosis.Brain communications · 2020Article
- Small vessel disease pathological changes in neurodegenerative and vascular dementias concomitant with autonomic dysfunction.Brain pathology (Zurich, Switzerland) · 2020Article
- Asymptomatic Cerebral Small Vessel Disease: Insights from Population-Based Studies.Journal of stroke · 2019Review
- Late-life blood pressure association with cerebrovascular and Alzheimer disease pathology.Neurology · 2018Article
- Does pathology of small venules contribute to cerebral microinfarcts and dementia?Journal of neurochemistry · 2018Review
- Clinical vascular imaging in the brain at 7T.NeuroImage · 2018Review
- Characterization of ApoJ-reconstituted high-density lipoprotein (rHDL) nanodisc for the potential treatment of cerebral β-amyloidosis.Scientific reports · 2017Article
- Functional deficits induced by cortical microinfarcts.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeSome studies have reported associations between intracranial atherosclerosis and Alzheimer disease pathology. We aimed to correlate severity of cerebral atherosclerosis, arteriolosclerosis, and cerebral amyloid angiopathy with neurofibrillary tangles, neuritic plaques, and cerebral infarcts.
methodsThis autopsy study (n=163) was drawn from a longitudinal study of subcortical ischemic vascular disease, Alzheimer disease, and normal aging. Multivariable logistic regression models were used to test associations among the 3 forms of cerebrovascular disease and the presence of ischemic and neurodegenerative brain lesions. Apolipoprotein E genotype was included as a covariate in these multivariable models.
resultsCerebral atherosclerosis was positively associated with microinfarcts (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.2-4.4) and cystic infarcts (OR, 2.0; 95% CI, 1.0-4.2) but not Alzheimer disease pathology. Arteriolosclerosis showed a positive correlation with lacunar infarcts (OR, 2.0; 95% CI, 1.0-4.2) but not Alzheimer disease pathology. Cerebral amyloid angiopathy was inversely associated with lacunar infarcts (OR, 0.6; 95% CI, 0.41-1.1), but positively associated with Braak and Braak stage (OR, 1.5; 95% CI, 1.1-2.1) and Consortium to Establish a Registry for Alzheimer Disease plaque score (OR, 1.5; 95% CI, 1.1-2.2).
conclusionsMicroinfarcts, which have been correlated with severity of cognitive impairment, were most strongly associated with atherosclerosis. Possible pathogenetic mechanisms include artery-to-artery emboli, especially microemboli that may include atheroemboli or platelet-fibrin emboli. Arteriolosclerosis was positively, whereas cerebral amyloid angiopathy was negatively correlated with lacunar infarcts, which might prove helpful in clinical differentiation of arteriolosclerotic from cerebral amyloid angiopathy-related vascular brain injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.