ArticleClinical research in cardiology : official journal of the German Cardiac Society2013
Reperfusion therapy and mortality in octogenarian STEMI patients: results from the Belgian STEMI registry.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Invasive Strategy With Intended Percutaneous Coronary Intervention Versus Conservative Treatment in Older People With ST-Segment-Elevation Myocardial Infarction: A Meta-Analysis.Journal of the American Heart Association · 2025Pooled it
- Drug-eluting stents in patients with anterior STEMI undergoing primary angioplasty: a substudy of the DESERT cooperation.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Pooled it
- Leukocyte telomere length and left ventricular function after acute ST-elevation myocardial infarction: data from the glycometabolic intervention as adjunct to primary coronary intervention in ST elevation myocardial infarction (GIPS-III) trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Trial
- Implementation of the ESC STEMI guidelines in female and elderly patients over a 20-year period in a large German registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Two-Year clinical outcomes after coronary bifurcation stenting in older patients from Korea and Italy.Frontiers in cardiovascular medicine · 2023Article
- Age-Related Mortality in STEMI Patients: Insight from One Year of HUB Centre Experience during the Pandemic.Journal of cardiovascular development and disease · 2022Article
- Chest pain and acute coronary syndrome in octogenarians admitted to the Emergency Department.Aging clinical and experimental research · 2021Article
- Elderly Suffering from ST-Segment Elevation Myocardial Infarction-Results from a Database Analysis from Two Mediterranean Medical Centers.Journal of clinical medicine · 2021Article
- Clinical characteristics and outcomes of octogenarians presenting with ST elevation myocardial infarction in the Australian population.World journal of cardiology · 2017Article
- Coronary procedures in German hospitals: a detailed analysis for specific patient clusters.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Article
- Acute coronary syndromes in octogenarians referred for invasive evaluation: treatment profile and outcomes.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Article
- Uncommon cause of ST-segment elevation in V1-V3: incremental value of cardiac magnetic resonance imaging.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Article
- Short-term outcome of patients with ST-segment elevation myocardial infarction (STEMI) treated with an everolimus-eluting bioresorbable vascular scaffold.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Observational
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Authors and funding
15 authors at 12 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTreatment strategies and outcome of ST-elevation myocardial infarction (STEMI) have been mainly studied in middle-aged patients. With increasing lifetime expectancy, the proportion of octogenarians will substantially increase. We aimed to evaluate whether the benefit of currently recommended reperfusion strategies is maintained in octogenarians.
methodsReperfusion therapy and in-hospital mortality were evaluated in 1,092 octogenarians and compared with 7,984 STEMI patients <80 years old based on data from the prospective Belgian STEMI registry.
resultsThe octogenarian STEMI group had more cardiovascular comorbidities, contained more female patients and presented more frequently with cardiac failure (Killip class >1, 40 vs. 20 %) compared with their younger counterparts (all p < 0.05). Although the rate of thrombolysis was similar (9.2 vs. 9.9 %) between both groups, a conservative approach was chosen more frequently (13.8 vs. 4.7 %), while PCI was performed less frequently (76.9 vs. 85.4 %) in octogenarians (p < 0.001). Moreover, ischemic time and door-to-needle/balloon time were longer for octogenarians. In-hospital mortality for octogenarians was 17.8 vs. 5.5 % in the younger group [adjusted OR 2.43(1.92-3.08)]. In haemodynamically stable octogenarians, PCI seemed to improve outcome compared with thrombolysis or conservative treatment (5.7 vs. 12.7 vs. 8.5 %, p = 0.09). In octogenarians with cardiac failure, in-hospital mortality was extremely high independent of the chosen reperfusion therapy (34.6 vs. 31.6 vs. 36.3 %, p = 0.88).
conclusionsIn-hospital mortality in octogenarian STEMI patients was high and related to a high prevalence of cardiac failure. Less PCI was performed in the octogenarian group compared with the younger patients, although mortality benefit of PCI was maintained in haemodynamically stable octogenarians.
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