Evidence map›Paper›PMID 23887819›Full record

ArticleSocial cognitive and affective neuroscience2014

Neurobiology of placebo effects: expectations or learning?

Marta Peciña, Christian S Stohler, Jon-Kar Zubieta

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Social cognitive and affective neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Expectancy Modulation of Opioid Neurotransmission.International review of neurobiology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Marta PeciñaDepartment of Psychiatry, Molecular and Behavioral Neuroscience Institute and Department of Radiology, Medical School, University of Michigan, Ann Arbor, MI, USA, and School of Dentistry, University of Maryland, Baltimore, MD, USA.
Christian S StohlerDepartment of Psychiatry, Molecular and Behavioral Neuroscience Institute and Department of Radiology, Medical School, University of Michigan, Ann Arbor, MI, USA, and School of Dentistry, University of Maryland, Baltimore, MD, USA.
Jon-Kar ZubietaDepartment of Psychiatry, Molecular and Behavioral Neuroscience Institute and Department of Radiology, Medical School, University of Michigan, Ann Arbor, MI, USA, and School of Dentistry, University of Maryland, Baltimore, MD, USADepartment of Psychiatry, Molecular and Behavioral Neuroscience Institute and Department of Radiology, Medical School, University of Michigan, Ann Arbor, MI, USA, and School of Dentistry, University of Maryland, Baltimore, MD, USADepartment of Psychiatry, Molecular and Behavioral Neuroscience Institute and Department of Radiology, Medical School, University of Michigan, Ann Arbor, MI, USA, and School of Dentistry, University of Maryland, Baltimore, MD, USA zubieta@umich.edu.
University of Michigan–Ann Arbor · USUniversity of Maryland, Baltimore · US

Funding

Interaction of Smoking and Chronic Pain at Neurochemical and Phenotypic LevelsR01DA027494 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZUBIETA, JON-KAR · 2009 to 2014
$2.6M
Neurochemistry of Opiate Abuse Risk in Chronic PainR01DA022520 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZUBIETA, JON-KAR · 2006 to 2012
$2.2M
NIDA NIH HHS R01 DA 022520NIDA NIH HHS R01 DA022520NIDA NIH HHS R01 DA 027494NIDA NIH HHS R01 DA027494
6 · The paper itself

Abstract

Contemporary learning theories suggest that conditioning is heavily dependent on the processing of prediction errors, which signal a discrepancy between expected and observed outcomes. This line of research provides a framework through which classical theories of placebo effects, expectations and conditioning, can be reconciled. Brain regions related to prediction error processing [anterior cingulate cortex (ACC), orbitofrontal cortex or the nucleus accumbens] overlap with those involved in placebo effects. Here we examined the possibility that the magnitude of objective neurochemical responses to placebo administration would depend on individual expectation-effectiveness comparisons. We show that such comparisons and not expectations per se predict behavioral placebo responses and placebo-induced activation of µ-opioid receptor-mediated neurotransmission in regions relevant to error detection (e.g. ACC). Expectations on the other hand were associated with greater µ-opioid system activation in the dorsolateral prefrontal cortex but not with greater behavioral placebo responses. The results presented aid the elucidation of molecular and neural mechanisms underlying the relationship between expectation-effectiveness associations and the formation of placebo responses, shedding light on the individual differences in learning and decision making. Expectation and outcome comparisons emerge as a cognitive mechanism that beyond reward associations appears to facilitate the formation and sustainability of placebo responses.

Indexed as

Placebo EffectAdultAnticipation, PsychologicalBrainFemaleHumansLearningMalePainPhysical StimulationPositron-Emission TomographyReceptors, Opioid, muSaline Solution, HypertonicYoung AdultReceptors, Opioid, muSaline Solution, Hypertonicexpectationsplacebo analgesiaprediction error signal and learningµ-opioid receptor

Identifiers

PMID23887819
PMCPMC4090967
OpenAlexW2132503940

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.