Evidence map›Paper›PMID 23887811›Full record

SynthesisSocial cognitive and affective neuroscience2014

Informatic parcellation of the network involved in the computation of subjective value.

John A Clithero, Antonio Rangel

Abstract readMeta-Analysis
In one paragraph

Synthesis in Social cognitive and affective neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 377 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
377citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

377 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  11. Trial
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  14. Review
  15. Common and Distinct Neural Substrates for Approach- and Avoidance-Motivated Actions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
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317 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

John A ClitheroDivision of the Humanities and Social Sciences and Computation and Neural Systems, California Institute of Technology, Pasadena, CA 91125, USA clithero@hss.caltech.edu.
Antonio RangelDivision of the Humanities and Social Sciences and Computation and Neural Systems, California Institute of Technology, Pasadena, CA 91125, USA Division of the Humanities and Social Sciences and Computation and Neural Systems, California Institute of Technology, Pasadena, CA 91125, USA.

Funding

The Neurobiology of Social Decision-Making: Social Inference and ContextP50MH094258 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI O'DOHERTY, JOHN P · 2012 to 2021
$18.6M
NIMH NIH HHS P50 MH094258
6 · The paper itself

Abstract

Understanding how the brain computes value is a basic question in neuroscience. Although individual studies have driven this progress, meta-analyses provide an opportunity to test hypotheses that require large collections of data. We carry out a meta-analysis of a large set of functional magnetic resonance imaging studies of value computation to address several key questions. First, what is the full set of brain areas that reliably correlate with stimulus values when they need to be computed? Second, is this set of areas organized into dissociable functional networks? Third, is a distinct network of regions involved in the computation of stimulus values at decision and outcome? Finally, are different brain areas involved in the computation of stimulus values for different reward modalities? Our results demonstrate the centrality of ventromedial prefrontal cortex (VMPFC), ventral striatum and posterior cingulate cortex (PCC) in the computation of value across tasks, reward modalities and stages of the decision-making process. We also find evidence of distinct subnetworks of co-activation within VMPFC, one involving central VMPFC and dorsal PCC and another involving more anterior VMPFC, left angular gyrus and ventral PCC. Finally, we identify a posterior-to-anterior gradient of value representations corresponding to concrete-to-abstract rewards.

Indexed as

Brain MappingMathematicsRewardBrainDecision MakingFemaleHumansImage Processing, Computer-AssistedLikelihood FunctionsMagnetic Resonance ImagingMaleNeural PathwaysOxygenPubMedOxygendecision makingfMRIIBMAmeta-analysisvalue

Identifiers

PMID23887811
PMCPMC4158359

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.