SynthesisRevista Brasileira de terapia intensiva2013
Biomarkers in septic encephalopathy: a systematic review of clinical studies.
Synthesis in Revista Brasileira de terapia intensiva, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Mechanism-informed diagnostic accuracy of blood biomarkers for sepsis-associated encephalopathy: a systematic review and Bayesian diagnostic network meta-analysis.Frontiers in molecular neuroscience · 2026Pooled it
- Pooled it
- Compare Serum VCAM-1, NSE, Procalcitonin in Predict Sepsis Induced Encephalopathy in Septic Patients.Journal of clinical laboratory analysis · 2026Article
- Paediatric sepsis-associated encephalopathy (SAE): a comprehensive review.Molecular medicine (Cambridge, Mass.) · 2023Review
- Clinical features, electroencephalogram, and biomarkers in pediatric sepsis-associated encephalopathy.Scientific reports · 2022Article
- Acoustocerebrography in septic patients: A randomized and controlled pilot study.Frontiers in medical technology · 2022Article
- Basic research and clinical progress of sepsis-associated encephalopathy.Journal of intensive medicine · 2021Review
- Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care. NHLBI Working Group Report.American journal of respiratory and critical care medicine · 2020Article
- Metformin Attenuates Brain Injury by Inhibiting Inflammation and Regulating Tight Junction Proteins in Septic Rats.Cell journal · 2020Article
- The dynamic change of serum S100B levels from day 1 to day 3 is more associated with sepsis-associated encephalopathy.Scientific reports · 2020Article
- Observational
- Cerebral blood flow and serum neuron-specific enolase in early-onset neonatal sepsis.Pediatric research · 2018Observational
- Translational evidence for two distinct patterns of neuroaxonal injury in sepsis: a longitudinal, prospective translational study.Critical care (London, England) · 2017Article
- The Severity of Cecal Ligature and Puncture-Induced Sepsis Correlates with the Degree of Encephalopathy, but the Sepsis Does Not Lead to Acute Activation of Spleen Lymphocytes in Mice.Molecular neurobiology · 2016Article
- Significance of Serum Neuron-Specific Enolase in Patients With Sepsis and Its Association With Inflammatory Biomarkers.Acute medicine & surgeryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to systematically review the importance of neuron-specific enolase and S100 beta for diagnosing and monitoring septic encephalopathy.
methodsA PubMed database search was performed to identify studies that evaluated S100 beta and neuron-specific enolase serum levels in patients with sepsis and that were published between January 2000 and April 2012. Only human studies that employed an additional method of neurological assessment were selected.
resultsNine studies were identified, seven of which associated high concentrations of S100 beta and neuron-specific enolase with the development of septic encephalopathy. Four studies also associated these concentrations with increased mortality. However, two studies did not find such an association when they evaluated S100 beta levels, and one of these studies did not observe a correlation between neuron-specific enolase and septic encephalopathy.
conclusionS100 beta and neuron-specific enolase are promising biomarkers for diagnosing and monitoring patients with septic encephalopathy, but more research is necessary.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.