Evidence map›Paper›PMID 23887688›Full record

ArticleCPT: pharmacometrics & systems pharmacology2013

Basic concepts in population modeling, simulation, and model-based drug development-part 2: introduction to pharmacokinetic modeling methods.

D R Mould, R N Upton

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CPT: pharmacometrics & systems pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 456 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
456citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06042803 recruitingnot on this mapstarted 2023, after this paper: background citation

Clinical Lactation Study on the Exposure to Medicines Via Human Milk: an Umbrella Study Protocol

TypeobservationalSponsorUniversitaire Ziekenhuizen KU LeuvenRan2023 to 2027Enrolled30ConditionsBreast Feeding, Human MilkArmsHuman milk collection, Optionally: maternal blood sample, Optionally: child blood sample
NCT06088849 nacompletednot on this mapstarted 2021, after this paper: background citation

Maternal Treatment With ACE-inhibitors and Breastfeeding: a Mono-centric Study on the Exposure Through Breast Milk

TypeinterventionalSponsorUniversitaire Ziekenhuizen KU LeuvenRan2021 to 2023Enrolled20ConditionsBreast Feeding, Hypertension, Heart Failure, ProteinuriaArmsVenipuncture
3 · Its place in the literature

Who cites it

456 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  10. Pharmacokinetics of Dexamethasone in Tuberculous Meningitis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
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396 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

D R MouldProjections Research, Phoenixville, Pennsylvania, USA.
R N Upton

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID23887688
PMCPMC3636497

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.