ArticleCPT: pharmacometrics & systems pharmacology2012
From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part II-Sensitivity to Physiological and Physicochemical Properties.
Article in CPT: pharmacometrics & systems pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children.Pharmacogenomics · 2014Trial
- Evaluation of the Drug-Drug Interaction Potential of Cannabidiol Against UGT2B7-Mediated Morphine Metabolism Using Physiologically Based Pharmacokinetic Modeling.Pharmaceutics · 2024Article
- Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs).Methods in molecular biology (Clifton, N.J.) · 2021Article
- Dose-linearity of the pharmacokinetics of an intravenous [British journal of clinical pharmacology · 2019Article
- Age- and Genotype-Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate-Glucuronosyltransferases in Human Liver.Clinical pharmacology and therapeutics · 2019Article
- Effect of Age-Related Factors on the Pharmacokinetics of Lamotrigine and Potential Implications for Maintenance Dose Optimisation in Future Clinical Trials.Clinical pharmacokinetics · 2018Article
- PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants.CPT: pharmacometrics & systems pharmacology · 2018Article
- Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments.CPT: pharmacometrics & systems pharmacology · 2018Article
- Characterization of Contributing Factors to Variability in Morphine Clearance Through PBPK Modeling Implemented With OCT1 Transporter.CPT: pharmacometrics & systems pharmacology · 2017Article
- Predictive Performance of Physiologically Based Pharmacokinetic and Population Pharmacokinetic Modeling of Renally Cleared Drugs in Children.CPT: pharmacometrics & systems pharmacology · 2016Article
- Paracetamol pharmacokinetics and metabolism in young women.BMC anesthesiology · 2015Article
- Drug-induced renal damage in preterm neonates: state of the art and methods for early detection.Drug safety · 2015Review
- Response to: "Prediction of Voriconazole Non-Linear Pharmacokinetics Using a Paediatric Physiologically Based Pharmacokinetic Modelling Approach".Clinical pharmacokinetics · 2015Article
- Population pharmacokinetic modeling of Thymoglobulin(®) in children receiving allogeneic-hematopoietic cell transplantation: towards improved survival through individualized dosing.Clinical pharmacokinetics · 2015Article
- Simultaneous pharmacokinetic modeling of gentamicin, tobramycin and vancomycin clearance from neonates to adults: towards a semi-physiological function for maturation in glomerular filtration.Pharmaceutical research · 2014Article
- A neonatal amikacin covariate model can be used to predict ontogeny of other drugs eliminated through glomerular filtration in neonates.Pharmaceutical research · 2014Article
- Developmental changes in morphine clearance across the entire paediatric age range are best described by a bodyweight-dependent exponent model.Clinical drug investigation · 2013Article
- From pediatric covariate model to semiphysiological function for maturation: part I-extrapolation of a covariate model from morphine to Zidovudine.CPT: pharmacometrics & systems pharmacology · 2012Article
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Authors and funding
7 authors.
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Abstract
To develop a maturation function for drug glucuronidation in children, that can be used in population and physiologically based modeling approaches, the physiological and physicochemical basis of a semiphysiological glucuronidation function for children was untangled using Simcyp. The results show that using the currently available in vitro data, in vivo morphine and zidovudine clearances were under predicted by the physiologically based model in Simcyp. The maturation profile was similar to the clinically observed profile except for the first 2 weeks of life, and liver size and UGT2B7 ontogeny are the physiological drivers of the maturation of glucuronidation. Physicochemical drug parameters did not affect this maturation profile, although log P and pKa influenced the absolute value of clearance. The results suggest that the semiphysiological glucuronidation function for young children can be used to predict the developmental clearance profile of other UGT2B7 substrates, though scenarios with nonlinear kinetics and high-extraction ratios require further investigation.CPT: Pharmacometrics & Systems Pharmacology (2012) 1, e10; doi:10.1038/psp.2012.12; advance online publication 10 October 2012.
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