ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2014
Improved molecular classification of serrated lesions of the colon by immunohistochemical detection of BRAF V600E.
Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- Molecular and Immune Profiling of Sessile Serrated Adenomas/Polyps Reveals Prognostic Genes and Immune Cell Dynamics in Colorectal Cancer Progression.Applied biochemistry and biotechnology · 2026Article
- Whole Tumor Heterogeneity Topography (WTHT)-A New Approach for Assessment of Intratumor Mutational Heterogeneity in Colorectal Adenomas.International journal of molecular sciences · 2026Article
- Exploring WNT pathway dysregulation in serrated colorectal cancer for improved diagnostic and therapeutic strategies.Frontiers in genetics · 2025Article
- Prevalence, risk factors, and BRAF mutation of colorectal sessile serrated lesions among Vietnamese patients.World journal of clinical oncology · 2024Article
- Exploring the spectrum of serrated epithelium encountered in inflammatory bowel disease.Human pathology · 2023Review
- Sporadic hyperplastic polyp associated with above-average risk of developing metachronous colorectal cancer.American journal of cancer research · 2023Article
- Serrated Colorectal Lesions: An Up-to-Date Review from Histological Pattern to Molecular Pathogenesis.International journal of molecular sciences · 2022Review
- Evolving pathologic concepts of serrated lesions of the colorectum.Journal of pathology and translational medicine · 2020Review
- DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation.iScience · 2020Article
- Utility of BRAF VE1 Immunohistochemistry as a Screening Tool for Colorectal Cancer HarboringJournal of pathology and translational medicine · 2018Article
- Review
- Immunohistochemical expression profiles of BRAF (V600E/VE1) in serrated colon polyps in Turkish population.International journal of clinical and experimental pathology · 2017Article
- Molecular characteristics of colorectal serrated polyps and hyperplastic polyps: A STROBE compliant article.Medicine · 2016Observational
- Gastric Proteins MUC5AC and TFF1 as Potential Diagnostic Markers of Colonic Sessile Serrated Adenomas/Polyps.American journal of clinical pathology · 2016Article
- VE1 immunohistochemistry predicts BRAF V600E mutation status and clinical outcome in colorectal cancer.Oncotarget · 2015Article
- Detection of KRAS, NRAS and BRAF by mass spectrometry - a sensitive, reliable, fast and cost-effective technique.Diagnostic pathology · 2015Article
- A cautionary note on the immunohistochemical detection of BRAF v600e mutations in serrated lesions of the colon.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015Article
- BRAF V600E immunohistochemistry is reliable in primary and metastatic colorectal carcinoma regardless of treatment status and shows high intratumoral homogeneity.The American journal of surgical pathology · 2014Article
- Article
- IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions.World journal of gastroenterology · 2014Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BRAF V600E mutation in serrated lesions of the colon has been implicated as an important mutation and as a specific marker for the serrated carcinogenic pathway. Recent findings point to microvesicular hyperplastic polyps that have similar histologic and molecular features to sessile serrated adenomas/polyps, as potential colorectal carcinoma precursors. The aim of this study was to evaluate BRAF V600E mutation status by immunohistochemistry in serrated lesions of the colon with regard to histomorphology. We investigated 194 serrated lesions of the colon, comprising 42 sessile serrated adenomas/polyps, 16 traditional serrated adenomas, 136 hyperplastic polyps and 20 tubular/tubulovillous adenomas (conventional adenomas) with the novel BRAF V600E mutation-specific antibody VE1. In addition, BRAF exon 15 and KRAS exon 2 status was investigated by capillary sequencing in selected cases. All sessile serrated adenomas/polyps (42/42, 100%), 15/16 (94%) traditional serrated adenomas and 84/136 (62%) hyperplastic polyps were VE1+. None of the VE1- serrated lesions showed BRAF V600E mutation. Forty out of 42 (95%) sessile serrated adenomas/polyps displayed areas with microvesicular hyperplastic polyp-like features. In microvesicular hyperplastic polyps, VE1 positivity was significantly associated with nuclear atypia (P=0.003); however, nuclear atypia was also present in VE1- cases. Immunostaining with VE1 allows not only the detection of BRAF V600E mutation but also the correlation with histomorphology on a cellular level in serrated lesions. VE1 enables a subclassification of microvesicular hyperplastic polyps according to the mutation status. This improved classification of serrated lesions including immunohistochemical evaluation of BRAF V600E mutation may be the key to identify lesions with higher potential to progression into sessile serrated adenoma/polyp, and further to BRAF V600E-mutated colorectal cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.