ArticleBehavioural brain research2013
Sex differences and estrous cycle in female rats interact with the effects of fluoxetine treatment on fear extinction.
Article in Behavioural brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- The effect of SSRIs on fear learning: a systematic review and meta-analysis.Psychopharmacology · 2023Pooled it
- Effects of Sex, Estradiol, and Acute Stress on Spontaneous Recovery of a Conditioned Touchscreen Response in Rats.Neuroscience insights · 2026Article
- A novel finding on the sex-dependent role of BDNF and GSK-3beta in the medial prefrontal cortex in pain threshold changes in a rat model of fear conditioning with respect to the effect of extinction and the time period after conditioning.Experimental brain research · 2025Article
- Article
- Reproductive experience alters the effects of diazepam and fluoxetine on anxiety-like behaviour, fear extinction, and corticosterone levels in female rats.Psychopharmacology · 2023Article
- Estrous Cycle Mediates Midbrain Neuron Excitability Altering Social Behavior upon Stress.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- A comparative analysis of depressive-like behavior: Exploring sex-related differences and insights.PloS one · 2023Article
- Refinement of the stress-enhanced fear learning model of post-traumatic stress disorder: a behavioral and molecular analysis.Lab animal · 2022Article
- Strain-, Sex-, and Time-Dependent Antidepressant-like Effects of Cannabidiol.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Molecular motor protein KIF5C mediates structural plasticity and long-term memory by constraining local translation.Cell reports · 2021Article
- Sex differences in fear memory consolidation via Tac2 signaling in mice.Nature communications · 2021Article
- Effect of Estrous Cycle on Behavior of Females in Rodent Tests of Anxiety.Frontiers in psychiatry · 2021Review
- Divergent Response to the SSRI Citalopram in Male and Female Three-Spine Sticklebacks (Gasterosteus aculeatus).Archives of environmental contamination and toxicology · 2020Article
- Estrous Cycle Monitoring in Mice with Rapid Data Visualization and Analysis.Bio-protocol · 2019Article
- Sex differences in fear extinction.Neuroscience and biobehavioral reviews · 2019Review
- Fluoxetine Exposure During Sexual Development Disrupts the Stress Axis and Results in Sex- and Time- Dependent Effects on the Exploratory Behavior in Adult ZebrafishFrontiers in neuroscience · 2019Article
- Hippocampal neural progenitor cells play a distinct role in fear memory retrieval in male and female CIE rats.Neuropharmacology · 2018Article
- Early life stress impairs contextual threat expression in female, but not male, mice.Behavioral neuroscience · 2018Article
- Sex differences in the traumatic stress response: the role of adult gonadal hormones.Biology of sex differences · 2018Article
- Contribution of estradiol levels and hormonal contraceptives to sex differences within the fear network during fear conditioning and extinction.BMC psychiatry · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
A common treatment for anxiety disorders is chronic administration of selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine. Recent data suggest that SSRIs modulate fear responses after conditioned fear extinction and that gonadal hormones influence fear extinction. In this study we investigated the influence of sex and the estrous cycle on the effects of acute (experiment 1) and chronic (experiment 2) fluoxetine treatment on fear extinction. In experiment 1, rats received tone-footshock pairings during day 1. On day 2, rats received either fluoxetine (10mg/kg in 0.5mL) or vehicle prior to extinction learning. On day 3, extinction memory was assessed during extinction recall. In experiment 2, rats were exposed to a similar behavioral protocol, except that fluoxetine and vehicle were administered for 14 consecutives days after conditioning (days 2-15). Extinction learning and extinction recall occurred on days 15 and 16, respectively. Acute administration of fluoxetine increased fear responses equally in males and females during extinction learning and extinction recall. Chronic administration of fluoxetine reduced fear responses during extinction learning and extinction recall in female but not in male rats and this effect seems to be modulated by the estrous cycle. The SSRI-induced reduction of freezing during extinction learning and recall suggest a general anxiolytic effect of the drug treatment rather than a specific effect on extinction learning per se. Our data show evidence of sex-specific anxiolytic effects of 14-day treatment of fluoxetine while the acute anxiogenic effect of SSRI seems independent of sex effects.
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