ArticleVeterinary microbiology2013
Case-control study of microbiological etiology associated with calf diarrhea.
Article in Veterinary microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.
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Who cites it
99 citing papers in PubMed, 1 synthesis or guideline pooled it, 183 citations in OpenAlex.
- Cryptosporidium infections in terrestrial ungulates with focus on livestock: a systematic review and meta-analysis.Parasites & vectors · 2019Pooled it
- High prevalence of picobirnavirus genogroup I in calves without association with diarrhea in a dairy cattle herd, southeast Brazil.Veterinary research communications · 2026Article
- Combined use of dill essential oil and tannic acid creates stage-specific, and time-dependent antiviral effect against bovine viral pathogens (BoHV-1, BVDV, BPIV-3, BRSV, and BEV).Veterinary research communications · 2026Article
- Occurrence of respiratory and enteric bacteria and viruses in calves in Iceland.Acta veterinaria Scandinavica · 2026Article
- Detection and Genetic Diversity of Bovine Kobuvirus in Diarrheic Calves in Türkiye: Genomic Characterization and Comparative B-Cell Epitope Analysis.Animals : an open access journal from MDPI · 2026Article
- Differences in gut microbiome of Hanwoo (Korean indigenous cattle) calves as driven by bovine rotavirus and bovine coronavirus infection.Journal of animal science and technology · 2026Article
- Evaluating the presence of bovine coronavirus in diarrheic calves in Lahore, Punjab, Pakistan: a food security risk.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Characterizing fecal bioaerosols in dairy barns using microbial source tracking markers and bovine enteric viruses.Microbiology spectrum · 2026Article
- Clinical and Epidemiological Features of Calicivirus Infections in Cattle.Animals : an open access journal from MDPI · 2026Review
- First detection and characterization of Bovine parvovirus 2 and Bopivirus A in a neonatal calf with diarrhea in Iran through metagenomic RNA-seq.Virus genes · 2026Article
- Epidemiological insights into bovine viral diarrhea virus and bovine rotavirus in diarrheic Yaks on the Qinghai-Tibet Plateau.Frontiers in veterinary science · 2026Article
- Molecular characteristics of bovine norovirus and nebovirus in Swedish dairy herds.Acta veterinaria Scandinavica · 2025Article
- Diversity ofVeterinary sciences · 2025Article
- Importance and Characterisation of Concurrent Pathogens in Diarrhoeic Calves from North-Western Spain.Animals : an open access journal from MDPI · 2025Article
- Advances in diagnosis of diseases causing diarrhea in newborn calves.Veterinary research communications · 2025Review
- Major Etiological Agents Isolated from Neonatal Calf Diarrhea Outbreaks in Northern Italy.Pathogens (Basel, Switzerland) · 2025Article
- Molecular characterization of ten viral pathogens causing calf diarrhea in Hanwoo (Bos Taurus coreanae) by next generation sequencing.BMC veterinary research · 2025Article
- Bovine Coronavirus in diarrheic pre-weaned calves in Egypt: prevalence, risk factors, and the associated biochemical alterations.Tropical animal health and production · 2025Article
- The Therapeutic Potential of Gut-Microbiota-Derived Metabolite 4-Phenylbutyric Acid inInternational journal of molecular sciences · 2025Article
- Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calf diarrhea is a major economic burden for the US cattle industry. A variety of infectious agents are implicated in calf diarrhea and co-infection of multiple pathogens is not uncommon in diarrheic calves. A case-control study was conducted to assess infectious etiologies associated with calf diarrhea in Midwest cattle farms. A total of 199 and 245 fecal samples were obtained from diarrheic and healthy calves, respectively, from 165 cattle farms. Samples were tested by a panel of multiplex PCR assays for 11 enteric pathogens: bovine rotavirus group A (BRV-A), bovine coronavirus (BCoV), bovine viral diarrhea virus (BVDV), bovine enterovirus (BEV), bovine norovirus (BNoV), Nebovirus, bovine torovirus (BToV) Salmonella spp. (Salmonella), Escherichia coli (E. coli) K99(+), Clostridium perfringens with β toxin gene and Cryptosporidium parvum (C. parvum). The association between diarrhea and detection of each pathogen was analyzed using a multivariate logistic regression model. More than a half of the fecal samples from the diarrheic calves had multiple pathogens. Statistically, BRV-A, BCoV, BNoV, Nebovirus, Salmonella, E. coli K99(+), and C. parvum were significantly associated with calf diarrhea (p<0.05). Among them, C. parvum and BRV-A were considered to be the most common enteric pathogens for calf diarrhea with high detection frequency (33.7% and 27.1%) and strong odds ratio (173 and 79.9). Unexpectedly BNoV (OR=2.0) and Nebovirus (OR=16.7) were identified with high frequency in diarrheic calves, suggesting these viruses may have a significant contribution to calf diarrhea.
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Registered trials
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