Evidence map›Paper›PMID 23886406›Full record

ArticleThe Journal of arthroplasty2013

Topical tranexamic acid reduces blood loss and transfusion rates in total hip and total knee arthroplasty.

Gerhardt Konig, Brian R Hamlin, Jonathan H Waters

8 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of arthroplasty, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 8 registered trials, which are not on this map. Cited by 73 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 8 pooled it
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02056444 nacompletednot on this mapstarted 2014, after this paper: background citation

Tranexamic Acid Comparison in Hip Replacement (TeACH-R) Trial: Comparative Efficacy of Intravenous Versus Topical Tranexamic Acid for Reducing Blood Loss in Elective Primary Total Hip Arthroplasty.

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2014 to 2016Enrolled149ConditionsOsteoarthritisArmsTranexamic Acid
NCT02453802 phase4unknown statusnot on this mapstarted 2015, after this paper: background citation

Comparison of Topical and Infusion Tranexamic Acid on Blood Loss and Risk of Deep Vein Thrombosis After Total Knee Arthroplasty

TypeinterventionalSponsorChang Gung Memorial HospitalRan2015 to 2016Enrolled90ConditionsOsteoarthritis, KneeArmsTranexamic Acid 5%,5ml/amp, rivaroxaban (10mg), 0.9% Normal Saline
NCT02865174 phase4unknown statusnot on this mapstarted 2016, after this paper: background citation

Comparison of Topical Tranexamic Acid and Floseal® on Blood Loss After Total Knee Arthroplasty in Patients With a Thromboembolic Risk

TypeinterventionalSponsorChang Gung Memorial HospitalRan2016 to 2017Enrolled90ConditionsOsteoarthritis, KneeArmsTopical tranexamic acid, Floseal®, Enoxaparin
NCT03074994 phase2unknown statusnot on this mapstarted 2016, after this paper: background citation

The Comparative Efficacy of Peri-articular and Intraarticular Tranexamic Acid in Total Knee Arthroplasty: A Prospective, Double-Blind Randomized, Controlled Trial

TypeinterventionalSponsorThammasat UniversityRan2016 to 2019Enrolled108ConditionsOsteoarthritis,KneeArmsPeri-articular TXA (15 mg/kg), Intraarticular TXA 2 g (40 mL), TXA combined with multimodal local anesthetic infiltration inject into peri-articular area, TXA 40 mL inject into intraaricular knee capsule
NCT03328832 phase4completednot on this mapstarted 2017, after this paper: background citation

Comparison of Combined Topical Tranexamic Acid With Floseal® With Intravenous Tranexamic Acid on Blood Loss in Total Knee Arthroplasty

TypeinterventionalSponsorChang Gung Memorial HospitalRan2017 to 2018Enrolled70ConditionsOsteoarthritis, KneeArmsTopical tranexamic acid, Floseal®, rivaroxaban (10mg)
NCT03825939 phase4terminatednot on this mapstarted 2015, after this paper: background citation

Evaluating the Use of Tranexamic Acid (TXA) in Total Joint Arthroplasty

TypeinterventionalSponsorNYU Langone HealthRan2015 to 2016Enrolled52ConditionsBlood LossArmsIntravenous Placebo, Intravenous Tranexamic Acid
NCT03952546 nacompletednot on this mapstarted 2019, after this paper: background citation

A Prospective, Randomized, Single-blinded, Non-inferiority Study to Evaluate the Safety and Efficacy of the Saline-coupled Bipolar Sealer Compared to the Unipolar Electrocautery in Primary Unilateral Total Knee Arthroplasty

TypeinterventionalSponsorNorthwell HealthRan2019 to 2021Enrolled211ConditionsSurgical Blood LossArmsSaline-coupled Bipolar Sealer, Unipolar electrocautery
NCT05504577 phase4completednot on this mapstarted 2022, after this paper: background citation

Blood-saving Effect of Kaolin-based Hemostatic Gauze Combined With Intravenous Tranexamic Acid in Total Knee Arthroplasty

TypeinterventionalSponsorChang Gung Memorial HospitalRan2022 to 2023Enrolled140ConditionsTotal Blood Loss, Arthropathy of Knee JointArmsTranexamic acid injection, apply the QCG, apply surgical gauze
3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 8 syntheses or guidelines pooled it, 189 citations in OpenAlex.

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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Gerhardt KonigDepartment of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Brian R Hamlin
Jonathan H Waters
University of Pittsburgh · USUniversity of Pittsburgh Medical Center · US

Funding

Research Training in Anesthesiology and Pain MedicineT32GM075770 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YAN XU · 2007 to 2026
$4.8M
NIGMS NIH HHS T32 GM075770NIGMS NIH HHS T32GM075770
6 · The paper itself

Abstract

The objective of this study was to determine if tranexamic acid (TXA) applied topically reduced postoperative bleeding and transfusion rates after primary total hip arthroplasty (THA) and primary total knee arthroplasty (TKA). Two hundred and ninety consecutive patients from a single surgeon were enrolled. In TKA, TXA solution was injected into the knee after closure of the arthrotomy. In THA, the joint was bathed in TXA solution at three points during the procedure. In both THA and TKA the TXA solution was at a concentration of 3 g TXA per 100 mL saline. The mean blood loss was significantly higher in the non-TXA patients in both TKA and THA groups. Postoperative transfusions decreased dramatically with TXA, dropping from 10% to 0%, and from 15% to 1%, in the TKA and THA groups, respectively. Topical application of TXA significantly reduces postoperative blood loss and transfusion risk in TKA and THA.

Indexed as

Arthroplasty, Replacement, HipArthroplasty, Replacement, KneeAdministration, TopicalAgedAntifibrinolytic AgentsBlood TransfusionFemaleHumansMaleMiddle AgedPostoperative HemorrhageTranexamic AcidAntifibrinolytic AgentsTranexamic Acidantifibrinolyticblood transfusiontotal hip arthroplastytotal knee arthroplastytranexamic acid

Identifiers

PMID23886406
PMCPMC3807723
OpenAlexW1981196689

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

and 2 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.