Evidence map›Paper›PMID 2388631›Full record

ArticleMolecular and cellular biology1990

Highly repeated sites in the apolipoprotein(a) gene recognized by methylated DNA-binding protein, a sequence-specific DNA-binding protein.

K C Ehrlich, M Ehrlich

Abstract read
In one paragraph

Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. Genetic Variants and Haplotypes inDNA and cell biology · 2020
    Article
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  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

K C EhrlichSouthern Regional Research Center, U.S. Department of Agriculture, New Orleans, Louisiana 70179.
M Ehrlich
Southern Regional Research Center · US

Funding

RECOGNITION OF METHYLATED DNA BY MAMMALIAN PROTEINSR01GM033999 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI EHRLICH, MELANIE · 1985 to 1995
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NIGMS NIH HHS GM33999
6 · The paper itself

Abstract

Methylated DNA-binding protein (MDBP), a sequence-specific DNA-binding protein, was found to recognize more than 30 sites within an allele of the human apolipoprotein(a) gene. High plasma levels of apolipoprotein(a), a risk factor for atherosclerosis, have been correlated with genetically inherited lower-molecular-mass isoforms of this protein. MDBP might help down modulate the expression of the apolipoprotein(a) gene in a manner dependent on the length of a given allele of the gene and the number of MDBP sites in it.

Indexed as

GenesLipoprotein(a)Repetitive Sequences, Nucleic AcidAllelesApolipoproteinsApoprotein(a)Base SequenceBinding SitesCell LineCell NucleusDNA-Binding ProteinsGene Expression RegulationHumansMolecular Sequence DataSubstrate SpecificityApolipoproteinsApoprotein(a)DNA-Binding ProteinsLipoprotein(a)

Identifiers

PMID2388631
PMCPMC361120
OpenAlexW2112552033

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.