ArticleMuscles, ligaments and tendons journal2013
Original article Muscle extracellular matrix degradation and contractibility following tendon rupture and disuse.
Article in Muscles, ligaments and tendons journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Influence of Diabase Filler on the Structure and Tribological Properties of Coatings Based on Ultrahigh Molecular Weight Polyethylene.Polymers · 2023Article
- Pro-fibrogenic and adipogenic aspects of chronic muscle degeneration are contributed by distinct stromal cell subpopulations.PloS one · 2023Article
- Preconditioning improves muscle regeneration after ischemia-reperfusion injury.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- The Role of Detraining in Tendon Mechanobiology.Frontiers in aging neuroscience · 2016Review
- Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy.Muscles, ligaments and tendons journal · 2014Article
- Age-related greater Achilles tendon compliance is not associated with larger plantar flexor muscle fascicle strains in senior women.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Effectiveness of the Intratissue Percutaneous Electrolysis (EPI®) technique and isoinertial eccentric exercise in the treatment of patellar tendinopathy at two years follow-up.Muscles, ligaments and tendons journal · 2014Article
- Semitendinosus snapping: analysis of movement, electromyographic activities, muscle strength and endurance, motor control and joint position sense.Muscles, ligaments and tendons journal · 2013Article
- Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy.Muscles, ligaments and tendons journalArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Muscle extracellular matrix (ECM) plays an important role in maintaining muscular integrity and force transduction. However, the role of ECM in skeletal muscle atrophy remains unknown. In this study, we employed two clinically relevant mouse models of Achillotenotomy and hindlimb suspension to simulate Achilles tendon rupture and hindlimb disuse. The gastrocnemius was harvested following two weeks of treatment. We hypothesized that degradation of muscle ECM basement membrane lead to dysfunction of muscle contractility. Our results demonstrated a significant reduction of gastrocnemius single twitch force, isometric tetanic force, and contraction velocity following tendon rupture (p<0.001), but not disuse. Additionally, up-regulation of matrix metalloproteinase-2 (MMP-2) was observed only after tendon rupture (p=0.00234). These findings suggest that ECM remodeling and basement membrane degradation due to MMP-2 may be responsible for declined muscle contractibility. Inhibiting ECM degradation enzymes may be a potential treatment strategy for skeletal muscle atrophy after tendon rupture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.