ArticleAmerican journal of clinical and experimental immunology2012
Lipid-free apolipoprotein A-I exerts an antioxidative role against cell-free hemoglobin.
Article in American journal of clinical and experimental immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Cell-Free Hemoglobin in the Pathophysiology of Trauma: A Scoping Review.Critical care explorations · 2024Article
- Haptoglobin is dispensable for haemoglobin uptake byFrontiers in immunology · 2024Article
- Association of Serum Uric Acid with Non-Valvular Atrial Fibrillation: A Retrospective Study in China.International journal of general medicine · 2024Article
- Retrospective Study from a Single Center to Evaluate the Association Between Sex and Serum Uric Acid Levels in 950 Patients with Atrial Fibrillation.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- A Retrospective Study to Determine the Association Between Serum Albumin Levels and Atrial Fibrillation by Sex in 950 Patients from a Single Center in China.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Serum Uric Acid Levels in Relation to Atrial Fibrillation: A Case-Control Study.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Validation of the Performance of A1HPV6, a Triage Blood Test for the Early Diagnosis and Prognosis of SARS-CoV-2 Infection.Gastro hep advances · 2022Article
- Influence of High Hemoglobin-Oxygen Affinity on Humans During Hypoxia.Frontiers in physiology · 2021Review
- Comparison of apolipoprotein-A1 levels between paroxysmal atrial fibrillation patients and healthy subjects.Journal of cardiovascular and thoracic research · 2020Article
- Plasma proteomic changes during therapeutic hypothermia in resuscitated patients after cardiac arrest.Experimental and therapeutic medicine · 2019Article
- Immunological properties of oxygen-transport proteins: hemoglobin, hemocyanin and hemerythrin.Cellular and molecular life sciences : CMLS · 2017Review
- Hemoglobin expression in nonerythroid cells: novel or ubiquitous?International journal of inflammation · 2014Review
- Comparative plasma protein profiling of hemoglobin H disease.Disease markers · 2014Article
- A perspective on the role of extracellular hemoglobin on the innate immune system.DNA and cell biology · 2013Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell-free hemoglobin (Hb) resulting from hemolysis is redox-active. It disrupts the oxidoreducing microenvironment, shifting the balance unfavorably towards tissue cytotoxicity. Thus, immediate suppression of the Hb-redox activity and removal of the cell-free plasma Hb is vital for maintaining homeostasis and survival. Among several known Hb-binding plasma proteins, haptoglobin (Hp) is the primary antioxidant of Hb. However, Hb-mediated oxidative stress persists in the covalently bound Hb-Hp aggregates or when Hp is depleted during a severe hemolysis. We therefore inquired whether there is an alternative anti-oxidative defense tactic in the blood. Here, we identified an Hb-interactome in the plasma, constituting Hb, Hp and lipid-free apolipoprotein A-I (apoAI). We found that apoAI acts rapidly as a secondary antioxidant to interact with Hb and quench the Hb-redox activity. We showed that apoAI either acts independently or collaborates with Hp to downregulate Hb-redox activity. Following the association between apoAI and Hb, the apoAI facilitates the uptake of Hb by interacting with a scavenger receptor class B type 1 (SR-BI) displayed on macrophages and hepatocytes. Our findings suggest that apoAI mediates an efficient pathway for the elimination of cytotoxic Hb redox activity.
Indexed as
Identifiers
23885313PMC3714184W187403696What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.