ArticleHepatitis monthly2013
Probiotics as a novel treatment for non-alcoholic Fatty liver disease; a systematic review on the current evidences.
Article in Hepatitis monthly, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Urinary (1)H-NMR-based metabolic profiling of children with NAFLD undergoing VSL#3 treatment.International journal of obesity (2005) · 2015Trial
- Effects of lactic acid bacteria isolated from dairy products on lipid pattern of rats fed with a high fat diet.Iranian journal of microbiology · 2025Article
- Association between gut microbiota and locomotive syndrome risk in healthy Japanese adults: a cross-sectional study.npj aging · 2024Article
- The effect of holding a workshop (group and face-to-face training method) on nutrition adjustment on anthropometric indices in children with chronic liver disease.Journal of education and health promotion · 2022Article
- The effect of nutritional education program on micronutrient intake in children with chronic liver disease: A clinical trial.Journal of education and health promotion · 2021Article
- [Effects of Lactobacillus paracasei N1115 combined with fructooligosaccharides on non-alcoholic fatty liver disease induced by high-fat diet in mice].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2017Article
- Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanisms and Therapy.Nutrients · 2017Review
- Prediction and Diagnosis of Non-Alcoholic Fatty Liver Disease (NAFLD) and Identification of Its Associated Factors Using the Classification Tree Method.Iranian Red Crescent medical journal · 2016Article
- Non-alcoholic fatty liver disease in 2016.British medical bulletin · 2016Review
- Diet, Microbiota, Obesity, and NAFLD: A Dangerous Quartet.International journal of molecular sciences · 2016Review
- The Effect of Symbiotic Supplementation on Liver Enzymes, C-reactive Protein and Ultrasound Findings in Patients with Non-alcoholic Fatty Liver Disease: A Clinical Trial.International journal of preventive medicine · 2016Article
- Hepatic and fecal metabolomic analysis of the effects of Lactobacillus rhamnosus GG on alcoholic fatty liver disease in mice.Journal of proteome research · 2015Article
- Focus on emerging drugs for the treatment of patients with non-alcoholic fatty liver disease.World journal of gastroenterology · 2014Review
- Effect of probiotic administration on the intestinal microbiota, current knowledge and potential applications.World journal of gastroenterology · 2014Review
- Bile acid dysregulation, gut dysbiosis, and gastrointestinal cancer.Experimental biology and medicine (Maywood, N.J.) · 2014Review
- Modern approach to the clinical management of non-alcoholic fatty liver disease.World journal of gastroenterology · 2014Review
- Effects of resveratrol in experimental and clinical non-alcoholic fatty liver disease.World journal of hepatology · 2014Review
- Dietary habits and behaviors associated with nonalcoholic fatty liver disease.World journal of gastroenterology · 2014Review
- Meta-omic platforms to assist in the understanding of NAFLD gut microbiota alterations: tools and applications.International journal of molecular sciences · 2014Review
- Non-alcoholic fatty liver disease, diet and gut microbiota.EXCLI journal · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextNon-alcoholic fatty liver disease (NAFLD) is a chronic liver disease, with 5-10% of liver having extra fat. Increase in its prevalence in all age groups is linked with obesity and Type II diabetes. The treatment of NAFLD remains controversial. A growing body of evidence suggests a relation between overgrowth of gut microbiota with NAFLD and non-alcoholic steatohepatitis (NASH). The objective of this review is to provide an overview on experimental and clinical studies assessing all positive and negative effects of probiotics. EVIDENCE ACQUISITION: We made a critical appraisal on various types of documents published from 1999 to March 2012 in journals, electronic books, seminars, and symposium contexts including Medline, PubMed, and Cochrane Central Register of Controlled Trials databases. We used the key words: "non-alcoholic fatty liver disease, probiotics, non-alcoholic steatohepatitis, liver disease, and fatty liver".
resultsProbiotics, as biological factors, control the gut microbiota and result in its progression. It is in this sense that they are suggestive of a new and a natural way of promoting liver function. Correspondingly, limited evidence suggests that probiotics could be considered as a new way of treatment for NAFLD.
conclusionsVarious experimental studies and clinical trials revealed promising effects of probiotics in improving NAFLD; however given the limited experience in this field, generalization of probiotics as treatment of NAFLD needs substantiation through more trials with a larger sample sizes and with longer-term follow up.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.