ArticleFrontiers in neuroengineering2013
Optimal number of stimulation contacts for coordinated reset neuromodulation.
Article in Frontiers in neuroengineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Coordinated reset stimulation of plastic neural networks with spatially dependent synaptic connections.Frontiers in network physiology · 2024Article
- Synaptic network structure shapes cortically evoked spatio-temporal responses of STN and GPe neurons in a computational model.Frontiers in neuroinformatics · 2023Article
- Effect of subthalamic coordinated reset deep brain stimulation on Parkinsonian gait.Frontiers in neuroinformatics · 2023Article
- Shuffling Improves the Acute and Carryover Effect of Subthalamic Coordinated Reset Deep Brain Stimulation.Frontiers in neurology · 2022Article
- Leveraging deep learning to control neural oscillators.Biological cybernetics · 2021Article
- Long-Lasting Desynchronization Effects of Coordinated Reset Stimulation Improved by Random Jitters.Frontiers in physiology · 2021Article
- Analysis of neural clusters due to deep brain stimulation pulses.Biological cybernetics · 2020Article
- Acoustic coordinated reset therapy for tinnitus with perceptually relevant frequency spacing and levels.Scientific reports · 2019Article
- Phase model-based neuron stabilization into arbitrary clusters.Journal of computational neuroscience · 2018Article
- Acute effects and after-effects of acoustic coordinated reset neuromodulation in patients with chronic subjective tinnitus.NeuroImage. Clinical · 2017Article
- Article
- Control of abnormal synchronization in neurological disorders.Frontiers in neurology · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this computational study we investigate coordinated reset (CR) neuromodulation designed for an effective control of synchronization by multi-site stimulation of neuronal target populations. This method was suggested to effectively counteract pathological neuronal synchrony characteristic for several neurological disorders. We study how many stimulation sites are required for optimal CR-induced desynchronization. We found that a moderate increase of the number of stimulation sites may significantly prolong the post-stimulation desynchronized transient after the stimulation is completely switched off. This can, in turn, reduce the amount of the administered stimulation current for the intermittent ON-OFF CR stimulation protocol, where time intervals with stimulation ON are recurrently followed by time intervals with stimulation OFF. In addition, we found that the optimal number of stimulation sites essentially depends on how strongly the administered current decays within the neuronal tissue with increasing distance from the stimulation site. In particular, for a broad spatial stimulation profile, i.e., for a weak spatial decay rate of the stimulation current, CR stimulation can optimally be delivered via a small number of stimulation sites. Our findings may contribute to an optimization of therapeutic applications of CR neuromodulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.